C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000129223 Rapgef3-001 ENSMUSG00000022469 10090 - 15:97744953-97767798 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000129223
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000129223 3.492±1.47 1.206±0.41 1.208±0.11 2.441±0.77 2.644±0.82 2.221±0.09 10.162±0.48 0.348±0.13 8.489±1.42 0.584±0.07 3.047±0.89 2.905±1.73 1.006±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005YT CIL_0005YT_0002 CGP 15:97711019-97767972
CIL_0002OC CIL_0002OC_0002 CGP 15:97744770-97792692

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005737 IEA cytoplasm
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IEA membrane
GO:0017034 ISS Rap guanyl-nucleotide exchange factor activity
GO:0030552 IEA cAMP binding
GO:0032486 ISS Rap protein signal transduction
GO:0032854 ISS positive regulation of Rap GTPase activity
GO:0045766 ISS positive regulation of angiogenesis
GO:0045859 IEA regulation of protein kinase activity
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0061028 ISS establishment of endothelial barrier
GO:0071320 ISS cellular response to cAMP
GO:2000249 ISS regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000389212 RAPGEF3-017 protein_coding Homo_sapiens 0 3177
ENST00000395358 RAPGEF3-003 protein_coding Homo_sapiens 0 1792
ENST00000395360 RAPGEF3-002 retained_intron Homo_sapiens 0 1410
ENST00000405493 RAPGEF3-201 protein_coding Homo_sapiens 0 3151
ENST00000449771 RAPGEF3-001 protein_coding Homo_sapiens 0 3195
ENST00000466322 RAPGEF3-012 protein_coding Homo_sapiens 0 773
ENST00000473777 RAPGEF3-008 retained_intron Homo_sapiens 0 300
ENST00000476259 RAPGEF3-009 retained_intron Homo_sapiens 1.4013e-45 187
ENST00000479866 RAPGEF3-004 retained_intron Homo_sapiens 0 1175
ENST00000482843 RAPGEF3-005 retained_intron Homo_sapiens 0 1310
ENST00000488250 RAPGEF3-006 retained_intron Homo_sapiens 0 1168
ENST00000490387 RAPGEF3-010 retained_intron Homo_sapiens 0 254
ENST00000494764 RAPGEF3-011 retained_intron Homo_sapiens 0 296
ENST00000495465 RAPGEF3-019 nonsense_mediated_decay Homo_sapiens 0 1020
ENST00000495953 RAPGEF3-013 protein_coding Homo_sapiens 0 536
ENST00000547856 RAPGEF3-016 nonsense_mediated_decay Homo_sapiens 0 2540
ENST00000548434 RAPGEF3-014 nonsense_mediated_decay Homo_sapiens 0 592
ENST00000548919 RAPGEF3-007 protein_coding Homo_sapiens 0 1814
ENST00000549151 RAPGEF3-018 protein_coding Homo_sapiens 0 3151

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