C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000079337 RAPGEF3 9606 - 12:47734672-47771040 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000389212 RAPGEF3-017 47737257-47758856 protein_coding
  ENST00000395358 RAPGEF3-003 47744453-47758645 protein_coding
  ENST00000395360 RAPGEF3-002 47737256-47744906 retained_intron
  ENST00000405493 RAPGEF3-201 47734672-47758461 protein_coding
  ENST00000449771 RAPGEF3-001 47737058-47758645 protein_coding
  ENST00000466322 RAPGEF3-012 47749953-47758438 protein_coding
  ENST00000473777 RAPGEF3-008 47739167-47741898 retained_intron
  ENST00000476259 RAPGEF3-009 47739459-47740395 retained_intron
  ENST00000479866 RAPGEF3-004 47737256-47758838 retained_intron
  ENST00000482843 RAPGEF3-005 47737256-47758774 retained_intron
  ENST00000488250 RAPGEF3-006 47737257-47742292 retained_intron
  ENST00000490387 RAPGEF3-010 47738196-47739724 retained_intron
  ENST00000494764 RAPGEF3-011 47746857-47748912 retained_intron
  ENST00000495465 RAPGEF3-019 47747719-47751169 nonsense_mediated_decay
  ENST00000495953 RAPGEF3-013 47751170-47758183 protein_coding
  ENST00000547856 RAPGEF3-016 47737244-47758572 nonsense_mediated_decay
  ENST00000548434 RAPGEF3-014 47738744-47741602 nonsense_mediated_decay
  ENST00000548919 RAPGEF3-007 47737540-47771040 protein_coding
  ENST00000549151 RAPGEF3-018 47737246-47771034 protein_coding
  ENST00000549347 RAPGEF3-015 47752562-47758187 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastHeartKidneyMuscleOvaryTestisENST00000395358ENST00000395360ENST00000479866ENST00000482843
Transcript ID Breast Heart Kidney Muscle Ovary Testis
ENST00000395358 7.730±6.08 N/A N/A N/A 1.586±0.00 2.573±0.00
ENST00000395360 N/A N/A N/A 0.837±0.00 N/A 5.323±0.00
ENST00000479866 N/A 0.888±0.00 0.650±0.00 N/A N/A N/A
ENST00000482843 N/A N/A N/A 0.994±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005YT CIL_0005YT_0001 CGP 12:47709734-47771040
CIL_0002OC CIL_0002OC_0001 CGP 12:47734672-47782753

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005886 TAS plasma membrane
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0007165 TAS signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 TAS membrane
GO:0017034 IMP Rap guanyl-nucleotide exchange factor activity
GO:0019933 NAS cAMP-mediated signaling
GO:0030168 TAS platelet activation
GO:0030552 IEA cAMP binding
GO:0030822 NAS positive regulation of cAMP catabolic process
GO:0032486 IMP Rap protein signal transduction
GO:0032854 IMP positive regulation of Rap GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043547 IEA positive regulation of GTPase activity
GO:0044281 TAS small molecule metabolic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0045859 IEA regulation of protein kinase activity
GO:0050796 TAS regulation of insulin secretion
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0061028 IMP establishment of endothelial barrier
GO:0070062 IDA extracellular vesicular exosome
GO:0071320 IDA cellular response to cAMP
GO:2000249 IMP regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079291 rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 protein_coding Danio_rerio
ENSMUSG00000022469 Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 protein_coding Mus_musculus

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