C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATPase, Ca++ transporting, plasma membrane 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026463 Atp2b4 10090 - 1:133699457-133801041 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000048953 Atp2b4-201 133702674-133753747 protein_coding
  ENSMUST00000112264 Atp2b4-002 133713981-133753281 protein_coding
  ENSMUST00000125659 Atp2b4-003 133706311-133753681 protein_coding
  ENSMUST00000128692 Atp2b4-005 133753700-133801036 processed_transcript
  ENSMUST00000140810 Atp2b4-004 133716323-133717929 retained_intron
  ENSMUST00000143567 Atp2b4-001 133699457-133801041 protein_coding
  ENSMUST00000165602 Atp2b4-202 133702674-133753747 protein_coding
  ENSMUST00000167348 Atp2b4-203 133701639-133701881 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000048953ENSMUST00000125659ENSMUST00000143567ENSMUST00000165602
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000048953 N/A N/A 59.720±10.68 4.251±4.17 N/A 3.190±0.76 0.465±0.00 N/A N/A N/A 0.452±0.02 3.093±0.38 3.247±0.00 1.888±0.11
ENSMUST00000125659 10.422±0.00 1.724±0.71 N/A 21.578±0.00 2.045±0.34 7.142±0.97 1.080±0.16 1.253±0.00 0.159±0.00 2.300±0.21 N/A 4.824±1.20 0.819±0.51 5.520±0.72
ENSMUST00000143567 2.924±0.14 0.757±0.23 9.927±1.33 N/A 1.034±0.21 2.253±0.15 0.511±0.04 0.419±0.09 0.925±0.94 0.976±0.32 0.166±0.03 2.081±0.56 N/A N/A
ENSMUST00000165602 18.978±1.29 2.595±0.14 N/A 4.385±0.00 5.227±0.96 5.395±1.23 2.303±0.25 2.450±0.31 7.168±8.32 4.242±0.48 1.557±0.18 6.471±2.41 3.169±1.62 7.959±2.73

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W2 CIL_0008W2_0002 VISTA 1:133249313-133850886
CIL_00096T CIL_00096T_0002 VISTA 1:133444227-134045719
CIL_0005VX CIL_0005VX_0002 CGP 1:133699457-133907999

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005388 IEA calcium-transporting ATPase activity
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006816 TAS calcium ion transport
GO:0006874 IEA cellular calcium ion homeostasis
GO:0008152 IEA metabolic process
GO:0010751 IEA negative regulation of nitric oxide mediated signal transduction
GO:0017080 IMP sodium channel regulator activity
GO:0030018 IEA Z disc
GO:0030315 IDA T-tubule
GO:0030346 IEA protein phosphatase 2B binding
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0036487 IEA nitric-oxide synthase inhibitor activity
GO:0042383 IDA sarcolemma
GO:0043234 IDA protein complex
GO:0045019 IEA negative regulation of nitric oxide biosynthetic process
GO:0046872 IEA metal ion binding
GO:0050998 IEA nitric-oxide synthase binding
GO:0051001 IEA negative regulation of nitric-oxide synthase activity
GO:0051599 IEA response to hydrostatic pressure
GO:0070588 IEA calcium ion transmembrane transport
GO:0070885 IEA negative regulation of calcineurin-NFAT signaling cascade
GO:0071872 IEA cellular response to epinephrine stimulus
GO:0097110 IPI scaffold protein binding
GO:0098736 IEA negative regulation of the force of heart contraction
GO:1900082 IEA negative regulation of arginine catabolic process
GO:1901205 IEA negative regulation of adrenergic receptor signaling pathway involved in heart process
GO:1902083 NAS negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305 IC regulation of sodium ion transmembrane transport
GO:1903243 IMP negative regulation of cardiac muscle hypertrophy in response to stress
GO:1903249 IEA negative regulation of citrulline biosynthetic process
GO:2000481 IEA positive regulation of cAMP-dependent protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044902 atp2b4 ATPase, Ca++ transporting, plasma membrane 4 protein_coding Danio_rerio
ENSG00000058668 ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 protein_coding Homo_sapiens

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