C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028613 Lrp8 10090 + 4:107802261-107876840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030356 Lrp8-006 107802314-107873899 protein_coding
  ENSMUST00000106731 Lrp8-003 107830985-107876840 protein_coding
  ENSMUST00000106732 Lrp8-002 107802413-107872346 protein_coding
  ENSMUST00000106733 Lrp8-007 107802277-107872816 protein_coding
  ENSMUST00000123140 Lrp8-004 107823161-107872816 processed_transcript
  ENSMUST00000126573 Lrp8-008 107802413-107872816 protein_coding
  ENSMUST00000135022 Lrp8-012 107850128-107856864 processed_transcript
  ENSMUST00000135591 Lrp8-011 107846201-107848295 retained_intron
  ENSMUST00000143601 Lrp8-001 107802261-107874167 nonsense_mediated_decay
  ENSMUST00000145832 Lrp8-005 107830965-107837221 retained_intron
  ENSMUST00000146552 Lrp8-009 107803251-107872816 processed_transcript
  ENSMUST00000147319 Lrp8-010 107802842-107851362 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030356ENSMUST00000106731ENSMUST00000106732ENSMUST00000106733ENSMUST00000123140ENSMUST00000126573ENSMUST00000135022ENSMUST00000135591ENSMUST00000143601ENSMUST00000146552ENSMUST00000147319
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030356 0.089±0.04 0.487±0.16 0.066±0.00 7.002±2.45 N/A 0.512±0.07 0.108±0.06 0.252±0.07 0.906±0.61 0.173±0.01 0.027±0.00 2.625±2.06 13.840±14.31 6.110±1.22
ENSMUST00000106731 0.145±0.11 N/A N/A 40.342±7.72 0.446±0.06 0.268±0.07 0.154±0.02 N/A 0.878±0.55 0.215±0.01 0.016±0.01 1.631±0.41 0.657±0.00 5.915±2.20
ENSMUST00000106732 0.424±0.12 N/A N/A N/A 0.402±0.17 N/A N/A N/A 0.962±0.00 0.149±0.02 0.037±0.02 2.855±0.22 14.401±13.57 8.161±0.43
ENSMUST00000106733 0.229±0.10 0.761±0.22 0.125±0.00 N/A 0.461±0.31 0.460±0.30 0.098±0.02 N/A 0.050±0.03 0.291±0.00 N/A 4.210±2.24 N/A 9.675±0.46
ENSMUST00000123140 N/A 0.460±0.04 N/A N/A N/A N/A N/A N/A 0.018±0.00 N/A N/A N/A N/A 7.349±0.00
ENSMUST00000126573 N/A N/A N/A N/A N/A N/A 0.102±0.00 N/A 0.038±0.00 N/A N/A N/A N/A N/A
ENSMUST00000135022 0.290±0.00 2.597±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000135591 N/A 1.580±0.46 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.922±0.00 N/A N/A
ENSMUST00000143601 N/A N/A N/A N/A N/A 0.310±0.00 0.143±0.00 N/A N/A N/A N/A 1.150±0.00 N/A N/A
ENSMUST00000146552 0.128±0.08 0.878±0.31 N/A N/A 0.551±0.34 0.687±0.13 0.195±0.07 0.796±0.34 0.806±0.72 0.364±0.11 N/A 3.825±1.31 9.751±12.06 N/A
ENSMUST00000147319 N/A N/A N/A N/A N/A N/A N/A N/A 0.120±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00083F CIL_00083F_0002 VISTA 4:107302048-107904613

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001948 IPI glycoprotein binding
GO:0005041 TAS low-density lipoprotein receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005875 IEA microtubule associated complex
GO:0005886 TAS plasma membrane
GO:0005901 IEA caveola
GO:0006897 IEA endocytosis
GO:0006898 TAS receptor-mediated endocytosis
GO:0008035 IEA high-density lipoprotein particle binding
GO:0014069 IEA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019894 IEA kinesin binding
GO:0021517 IEP ventral spinal cord development
GO:0021541 IMP ammon gyrus development
GO:0021766 IGI hippocampus development
GO:0021819 IGI layer formation in cerebral cortex
GO:0021987 IEA cerebral cortex development
GO:0030229 IEA very-low-density lipoprotein particle receptor activity
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032793 IMP positive regulation of CREB transcription factor activity
GO:0034185 IDA apolipoprotein binding
GO:0038025 IMP reelin receptor activity
GO:0038026 IMP reelin-mediated signaling pathway
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043235 ISO receptor complex
GO:0045860 IGI positive regulation of protein kinase activity
GO:0048306 IPI calcium-dependent protein binding
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 IMP regulation of synaptic transmission
GO:0061003 IMP positive regulation of dendritic spine morphogenesis
GO:0061098 IMP positive regulation of protein tyrosine kinase activity
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071397 IEA cellular response to cholesterol
GO:1900006 IGI positive regulation of dendrite development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070074 lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor protein_coding Danio_rerio
ENSG00000157193 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor protein_coding Homo_sapiens

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