C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myosin, heavy polypeptide 6, cardiac muscle, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040752 Myh6 10090 - 14:54941921-54966927 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081857 Myh6-201 54941921-54966607 protein_coding
  ENSMUST00000111456 Myh6-002 54965270-54966927 protein_coding
  ENSMUST00000124930 Myh6-004 54963958-54966574 protein_coding
  ENSMUST00000131892 Myh6-005 54957072-54957907 retained_intron
  ENSMUST00000134256 Myh6-003 54963958-54966605 protein_coding
  ENSMUST00000145322 Myh6-001 54952246-54966641 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000081857ENSMUST00000111456ENSMUST00000145322
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000081857 0.064±0.02 0.062±0.04 0.039±0.00 0.112±0.00 0.098±0.04 0.046±0.02 1615.017±58.74 0.134±0.07 0.011±0.01 28.156±7.04 0.292±0.07 0.090±0.04 0.038±0.02 0.037±0.01
ENSMUST00000111456 N/A N/A N/A N/A N/A 0.380±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000145322 0.015±0.01 N/A N/A N/A N/A 0.013±0.00 N/A 0.063±0.00 0.024±0.01 8.251±1.76 N/A 0.115±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00090C CIL_00090C_0002 VISTA 14:54638004-55241428
CIL_0009BW CIL_0009BW_0002 VISTA 14:54696106-55297707
CIL_0008Q4 CIL_0008Q4_0002 VISTA 14:54696894-55297224
CIL_0008QH CIL_0008QH_0002 VISTA 14:54703667-55304830
CIL_00051L CIL_00051L_0002 CGP 14:54936470-54966927
CIL_0004Z7 CIL_0004Z7_0008 CGP 14:54941921-54994634

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000146 IMP microfilament motor activity
GO:0001701 IMP in utero embryonic development
GO:0001725 IDA stress fiber
GO:0002026 IMP regulation of the force of heart contraction
GO:0002027 IMP regulation of heart rate
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005925 IEA focal adhesion
GO:0006200 IEA ATP catabolic process
GO:0006936 IEA muscle contraction
GO:0006941 IMP striated muscle contraction
GO:0007512 IMP adult heart development
GO:0007522 IMP visceral muscle development
GO:0008016 IMP regulation of heart contraction
GO:0008217 IMP regulation of blood pressure
GO:0016459 IDA myosin complex
GO:0016887 IEA ATPase activity
GO:0019901 IEA protein kinase binding
GO:0030016 IDA myofibril
GO:0030018 IDA Z disc
GO:0030048 IMP actin filament-based movement
GO:0030049 IEA muscle filament sliding
GO:0030239 IMP myofibril assembly
GO:0030509 IDA BMP signaling pathway
GO:0030898 IEA actin-dependent ATPase activity
GO:0032982 IEA myosin filament
GO:0043462 IMP regulation of ATPase activity
GO:0045214 IMP sarcomere organization
GO:0048739 IMP cardiac muscle fiber development
GO:0051015 IEA actin filament binding
GO:0055009 IEA atrial cardiac muscle tissue morphogenesis
GO:0055010 IEA ventricular cardiac muscle tissue morphogenesis
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060420 IDA regulation of heart growth

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045242 smyhc3 slow myosin heavy chain 3 protein_coding Danio_rerio
ENSDARG00000071430 smyhc1 slow myosin heavy chain 1 protein_coding Danio_rerio
ENSDARG00000071433 smyhc2 slow myosin heavy chain 2 protein_coding Danio_rerio
ENSDARG00000079564 vmhc ventricular myosin heavy chain protein_coding Danio_rerio
ENSDARG00000079782 vmhcl ventricular myosin heavy chain-like protein_coding Danio_rerio
ENSDARG00000092357 CU633479.5 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000092902 CR450736.2 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000093148 CU633479.6 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000093715 si:ch211-24n20.3 si:ch211-24n20.3 protein_coding Danio_rerio
ENSG00000197616 MYH6 myosin, heavy chain 6, cardiac muscle, alpha protein_coding Homo_sapiens

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