C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nucleophosmin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000057113 Npm1 10090 - 11:33152287-33163206 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000075641 Npm1-001 33152287-33163206 protein_coding
  ENSMUST00000093201 Npm1-006 33152510-33163072 protein_coding
  ENSMUST00000101375 Npm1-003 33155328-33163076 protein_coding
  ENSMUST00000109354 Npm1-002 33154927-33163077 protein_coding
  ENSMUST00000141881 Npm1-004 33152511-33154465 processed_transcript
  ENSMUST00000146759 Npm1-005 33156026-33157277 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000075641ENSMUST00000093201ENSMUST00000101375ENSMUST00000109354
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000075641 N/A 3.076±0.74 23.889±0.00 18.156±2.56 N/A N/A N/A N/A 57.077±30.47 4.084±0.00 34.263±8.46 173.154±10.35 77.150±54.38 7.582±0.91
ENSMUST00000093201 21.078±12.44 3.334±0.92 27.501±5.89 57.682±19.92 15.805±7.54 14.418±9.79 12.068±0.36 20.136±6.11 48.459±43.80 15.440±6.40 N/A 49.444±83.03 253.333±322.74 57.612±59.44
ENSMUST00000101375 64.800±43.20 15.903±5.10 96.421±30.52 143.238±52.39 42.973±9.89 47.542±13.12 30.795±2.48 46.074±7.44 147.055±171.71 47.434±2.00 12.245±3.89 58.472±10.66 768.322±800.31 59.820±31.43
ENSMUST00000109354 5.457±0.61 4.314±0.00 18.813±0.00 21.828±2.41 12.610±3.26 N/A N/A 9.659±0.00 117.711±88.49 8.476±0.00 N/A 61.425±49.83 241.301±186.66 7.933±0.25

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00092S CIL_00092S_0002 VISTA 11:32891798-33493112
CIL_00097F CIL_00097F_0002 VISTA 11:32999598-33601607
CIL_00088M CIL_00088M_0002 VISTA 11:33042866-33643782
CIL_000977 CIL_000977_0002 VISTA 11:33092412-33693558
CIL_00098H CIL_00098H_0002 VISTA 11:33099828-33701076
CIL_0008SG CIL_0008SG_0002 VISTA 11:33129906-33731024
CIL_0004OL CIL_0004OL_0002 CGP 11:33152287-33203589

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000055 IMP ribosomal large subunit export from nucleus
GO:0000056 IDA ribosomal small subunit export from nucleus
GO:0001652 IDA granular component
GO:0003723 IDA RNA binding
GO:0004860 ISS protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 ISS cytoplasm
GO:0005813 ISS centrosome
GO:0005829 IDA cytosol
GO:0006281 ISS DNA repair
GO:0006407 IDA rRNA export from nucleus
GO:0006884 IDA cell volume homeostasis
GO:0006913 IDA nucleocytoplasmic transport
GO:0007098 ISS centrosome cycle
GO:0007569 ISS cell aging
GO:0008104 IMP protein localization
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0010824 IMP regulation of centrosome duplication
GO:0010825 IGI positive regulation of centrosome duplication
GO:0015934 IDA large ribosomal subunit
GO:0015935 IDA small ribosomal subunit
GO:0016049 IDA cell growth
GO:0016607 IDA nuclear speck
GO:0019843 IDA rRNA binding
GO:0030529 ISO ribonucleoprotein complex
GO:0031328 IDA positive regulation of cellular biosynthetic process
GO:0032071 ISS regulation of endodeoxyribonuclease activity
GO:0042273 IDA ribosomal large subunit biogenesis
GO:0042274 IDA ribosomal small subunit biogenesis
GO:0043023 ISO ribosomal large subunit binding
GO:0043024 ISO ribosomal small subunit binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0043516 IGI regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044387 ISS negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727 ISS positive regulation of translation
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046599 ISS regulation of centriole replication
GO:0048025 IDA negative regulation of mRNA splicing, via spliceosome
GO:0051059 ISS NF-kappaB binding
GO:0051082 ISS unfolded protein binding
GO:0051259 ISO protein oligomerization
GO:0051726 IMP regulation of cell cycle
GO:0060699 ISS regulation of endoribonuclease activity
GO:0060735 ISS regulation of eIF2 alpha phosphorylation by dsRNA

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014329 npm1a nucleophosmin 1a protein_coding Danio_rerio
ENSG00000181163 NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) protein_coding Homo_sapiens

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