C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: arrestin, beta 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000108568 Arrb2-013 ENSMUSG00000060216 10090 + 11:70432637-70440674 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000108568
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000108568 3.087±0.51 1.516±0.57 1.935±0.47 8.582±3.21 6.091±2.21 1.205±0.18 1.088±0.29 1.219±0.22 3.515±2.53 3.643±0.13 0.948±0.39 3.653±3.32 2.277±0.96 0.548±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PS CIL_0001PS_0002 CGP 11:70392883-70440828
CIL_000106 CIL_000106_0002 CGP 11:70432635-70453727

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001664 IEA G-protein coupled receptor binding
GO:0001932 IDA regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002031 IEA G-protein coupled receptor internalization
GO:0002032 IEA desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 ISS positive regulation of receptor internalization
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005886 IEA plasma membrane
GO:0005905 IEA coated pit
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006897 IEA endocytosis
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007420 IEA brain development
GO:0007628 IMP adult walking behavior
GO:0008277 IMP regulation of G-protein coupled receptor protein signaling pathway
GO:0014069 IEA postsynaptic density
GO:0015031 IEA protein transport
GO:0016323 IEA basolateral plasma membrane
GO:0016567 IEA protein ubiquitination
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030139 ISS endocytic vesicle
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031410 IEA cytoplasmic vesicle
GO:0031623 IEA receptor internalization
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031691 IEA alpha-1A adrenergic receptor binding
GO:0031692 IEA alpha-1B adrenergic receptor binding
GO:0031701 IEA angiotensin receptor binding
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031748 IEA D1 dopamine receptor binding
GO:0031762 IEA follicle-stimulating hormone receptor binding
GO:0031826 IEA type 2A serotonin receptor binding
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032226 IMP positive regulation of synaptic transmission, dopaminergic
GO:0032403 IEA protein complex binding
GO:0032691 IMP negative regulation of interleukin-1 beta production
GO:0032695 IMP negative regulation of interleukin-12 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0032947 IEA protein complex scaffold
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0034260 IEA negative regulation of GTPase activity
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0042699 IEA follicle-stimulating hormone signaling pathway
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 IEA dendritic spine
GO:0043422 IPI protein kinase B binding
GO:0045211 IEA postsynaptic membrane
GO:0045953 IEA negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0051019 IEA mitogen-activated protein kinase binding
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051928 IEA positive regulation of calcium ion transport
GO:0060326 IEA cell chemotaxis
GO:0060765 IEA regulation of androgen receptor signaling pathway
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071889 IEA 14-3-3 protein binding
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000269260 ARRB2-002 protein_coding Homo_sapiens 0 1496
ENST00000346341 ARRB2-001 protein_coding Homo_sapiens 0 1345
ENST00000381488 ARRB2-009 protein_coding Homo_sapiens 0 1160
ENST00000412477 ARRB2-006 protein_coding Homo_sapiens 0 894
ENST00000570718 ARRB2-012 processed_transcript Homo_sapiens 0 351
ENST00000570739 ARRB2-011 processed_transcript Homo_sapiens 3e-20 102
ENST00000571206 ARRB2-008 protein_coding Homo_sapiens 0 1323
ENST00000571428 ARRB2-020 protein_coding Homo_sapiens 0 929
ENST00000571791 ARRB2-014 retained_intron Homo_sapiens 0 547
ENST00000572457 ARRB2-003 protein_coding Homo_sapiens 0 1225
ENST00000572497 ARRB2-016 nonsense_mediated_decay Homo_sapiens 0 324
ENST00000572782 ARRB2-015 retained_intron Homo_sapiens 2e-22 110
ENST00000573886 ARRB2-018 retained_intron Homo_sapiens 0 303
ENST00000574502 ARRB2-010 nonsense_mediated_decay Homo_sapiens 0 303
ENST00000574888 ARRB2-013 retained_intron Homo_sapiens 0 313
ENST00000574954 ARRB2-004 protein_coding Homo_sapiens 0 1323
ENST00000575131 ARRB2-017 retained_intron Homo_sapiens 0 505
ENST00000575877 ARRB2-007 protein_coding Homo_sapiens 0 1068
ENST00000576235 ARRB2-021 nonsense_mediated_decay Homo_sapiens 0 732
ENST00000577054 ARRB2-019 retained_intron Homo_sapiens 0 233

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