C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: patched homolog 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000021921 Ptch1-201 ENSMUSG00000021466 10090 - 13:63511533-63565520 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021921
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021921 12.157±5.41 15.767±2.95 3.023±0.14 7.991±1.70 11.150±6.48 2.301±0.64 6.321±3.77 3.640±1.74 16.532±6.94 0.503±0.10 33.105±9.28 1.663±0.93 1.808±0.73

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00086R CIL_00086R_0002 VISTA 13:63254160-63855734
CIL_0008KR CIL_0008KR_0002 VISTA 13:63268917-63869745
CIL_0002J8 CIL_0002J8_0002 CGP 13:63304709-63565520
CIL_0002J7 CIL_0002J7_0002 CGP 13:63511533-63900302

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001658 IMP branching involved in ureteric bud morphogenesis
GO:0001701 IGI in utero embryonic development
GO:0001841 IDA neural tube formation
GO:0001843 IMP neural tube closure
GO:0003007 IMP heart morphogenesis
GO:0005113 IDA patched binding
GO:0005119 IEA smoothened binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005901 IEA caveola
GO:0007165 IDA signal transduction
GO:0007224 IDA smoothened signaling pathway
GO:0007346 IMP regulation of mitotic cell cycle
GO:0007389 IMP pattern specification process
GO:0007420 IMP brain development
GO:0008158 TAS hedgehog receptor activity
GO:0008201 IDA heparin binding
GO:0008270 NAS zinc ion binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0008544 IMP epidermis development
GO:0008589 IMP regulation of smoothened signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0009887 IMP organ morphogenesis
GO:0009953 IGI dorsal/ventral pattern formation
GO:0010157 IDA response to chlorate
GO:0010875 IEA positive regulation of cholesterol efflux
GO:0014069 IEA postsynaptic density
GO:0014070 IEA response to organic cyclic compound
GO:0015485 TAS cholesterol binding
GO:0016485 IMP protein processing
GO:0021522 IGI spinal cord motor neuron differentiation
GO:0021532 IEA neural tube patterning
GO:0021904 IMP dorsal/ventral neural tube patterning
GO:0021997 IMP neural plate axis specification
GO:0030326 IGI embryonic limb morphogenesis
GO:0030332 IPI cyclin binding
GO:0030496 IDA midbody
GO:0030879 IMP mammary gland development
GO:0032355 IEA response to estradiol
GO:0032403 IDA protein complex binding
GO:0032526 IEA response to retinoic acid
GO:0032880 IDA regulation of protein localization
GO:0035108 IEA limb morphogenesis
GO:0035137 IMP hindlimb morphogenesis
GO:0040008 IMP regulation of growth
GO:0040015 IMP negative regulation of multicellular organism growth
GO:0042127 IMP regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616 IMP keratinocyte proliferation
GO:0044294 IEA dendritic growth cone
GO:0044295 IEA axonal growth cone
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045879 NAS negative regulation of smoothened signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048568 IGI embryonic organ development
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051782 IMP negative regulation of cell division
GO:0060037 IEA pharyngeal system development
GO:0060603 IMP mammary gland duct morphogenesis
GO:0060644 IMP mammary gland epithelial cell differentiation
GO:0060831 IMP smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005 IGI cell differentiation involved in kidney development
GO:0061053 IMP somite development
GO:0071397 IEP cellular response to cholesterol
GO:0072001 IEA renal system development
GO:0072203 IMP cell proliferation involved in metanephros development
GO:0072372 IDA primary cilium
GO:0072661 IEA protein targeting to plasma membrane
GO:0097108 IEA hedgehog family protein binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000121923 ptch1-202 protein_coding Danio_rerio 1e-35 158
ENST00000331920 PTCH1-001 protein_coding Homo_sapiens 0 5291
ENST00000375271 PTCH1-005 protein_coding Homo_sapiens 0 669
ENST00000375274 PTCH1-007 protein_coding Homo_sapiens 0 5123
ENST00000375290 PTCH1-015 nonsense_mediated_decay Homo_sapiens 0 2130
ENST00000418258 PTCH1-201 protein_coding Homo_sapiens 0 5118
ENST00000421141 PTCH1-202 protein_coding Homo_sapiens 0 5120
ENST00000429896 PTCH1-002 protein_coding Homo_sapiens 0 5116
ENST00000430669 PTCH1-003 protein_coding Homo_sapiens 0 5127
ENST00000437951 PTCH1-203 protein_coding Homo_sapiens 0 5118
ENST00000468211 PTCH1-006 protein_coding Homo_sapiens 0 782
ENST00000488809 PTCH1-004 retained_intron Homo_sapiens 0 243
ENST00000546744 PTCH1-018 retained_intron Homo_sapiens 0 859
ENST00000546820 PTCH1-010 protein_coding Homo_sapiens 0 1096
ENST00000547615 PTCH1-024 processed_transcript Homo_sapiens 0 612
ENST00000547672 PTCH1-009 protein_coding Homo_sapiens 0 1096
ENST00000548379 PTCH1-022 processed_transcript Homo_sapiens 0 662
ENST00000548420 PTCH1-019 protein_coding Homo_sapiens 0 399
ENST00000548945 PTCH1-013 processed_transcript Homo_sapiens 0 318
ENST00000549678 PTCH1-023 retained_intron Homo_sapiens 0 652
ENST00000550136 PTCH1-017 retained_intron Homo_sapiens 0 220
ENST00000550914 PTCH1-014 nonsense_mediated_decay Homo_sapiens 0 564
ENST00000551623 PTCH1-016 nonsense_mediated_decay Homo_sapiens 0 435
ENST00000551630 PTCH1-020 protein_coding Homo_sapiens 0 756
ENST00000551845 PTCH1-011 protein_coding Homo_sapiens 0 1092
ENST00000553011 PTCH1-012 protein_coding Homo_sapiens 0 1094
ENST00000553256 PTCH1-021 processed_transcript Homo_sapiens 0 527

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