C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034889 Hcn4-201 ENSMUSG00000032338 10090 + 9:58823512-58860955 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034889
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034889 0.283±0.18 0.529±0.09 0.025±0.00 2.236±1.06 0.694±0.31 0.052±0.01 2.374±0.04 0.091±0.02 0.009±0.00 0.251±0.09 0.223±0.06 0.233±0.09 0.105±0.06 0.043±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001701 IMP in utero embryonic development
GO:0002027 IEA regulation of heart rate
GO:0005222 IMP intracellular cAMP activated cation channel activity
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005249 IBA voltage-gated potassium channel activity
GO:0005515 IPI protein binding
GO:0005886 IEA plasma membrane
GO:0005887 IBA integral component of plasma membrane
GO:0006812 IMP cation transport
GO:0008016 IMP regulation of heart contraction
GO:0031226 IEA intrinsic component of plasma membrane
GO:0035725 IEA sodium ion transmembrane transport
GO:0042391 IBA regulation of membrane potential
GO:0042802 IEA identical protein binding
GO:0043195 IEA terminal bouton
GO:0071320 IEA cellular response to cAMP
GO:0071321 IEA cellular response to cGMP
GO:0071805 IBA potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000093300 hcn4-201 protein_coding Danio_rerio 0 1426
ENSDART00000136140 hcn4-001 protein_coding Danio_rerio 0 1426
ENSDART00000131044 HCN2 (2 of 2)-201 protein_coding Danio_rerio 0 1105
ENSDART00000113932 HCN1-201 protein_coding Danio_rerio 0 992
ENSDART00000151713 hcn3-201 protein_coding Danio_rerio 0 854
ENSDART00000039325 hcn3-001 protein_coding Danio_rerio 0 854
ENST00000251287 HCN2-001 protein_coding Homo_sapiens 0 1646
ENST00000261917 HCN4-001 protein_coding Homo_sapiens 0 4715
ENST00000368358 HCN3-001 protein_coding Homo_sapiens 0 1166
ENST00000467204 HCN3-003 processed_transcript Homo_sapiens 0 442
ENST00000496230 HCN3-002 processed_transcript Homo_sapiens 0 531
ENST00000568218 RP13-395E19.2-001 processed_pseudogene Homo_sapiens 0 1472
ENST00000569415 RP11-261B23.1-001 processed_pseudogene Homo_sapiens 0 1461
ENST00000572822 HCN3-002 processed_transcript Homo_sapiens 0 531
ENST00000575670 HCN3-001 protein_coding Homo_sapiens 0 1166
ENST00000576844 HCN3-003 processed_transcript Homo_sapiens 0 442

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