C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000090826 Rapgef4-001 ENSMUSG00000049044 10090 + 2:71981240-72257474 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonHeartLiverLungOvaryPlacentaTestisENSMUST00000090826
Transcript ID Adipose Adrenal Brain Colon Heart Liver Lung Ovary Placenta Testis
ENSMUST00000090826 0.687±0.14 6.776±0.00 3.918±0.79 0.149±0.00 1.845±0.34 0.368±0.04 0.626±0.00 1.420±0.32 0.169±0.08 0.372±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KA CIL_0004KA_0002 CGP 2:71873224-72257474
CIL_0003IJ CIL_0003IJ_0003 CGP 2:71981240-72442610

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005088 IDA Ras guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IEA membrane
GO:0017016 IPI Ras GTPase binding
GO:0017156 IDA calcium ion-dependent exocytosis
GO:0017157 IDA regulation of exocytosis
GO:0019933 IDA cAMP-mediated signaling
GO:0030073 IDA insulin secretion
GO:0030552 IDA cAMP binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0043547 IDA positive regulation of GTPase activity
GO:0045859 IEA regulation of protein kinase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000397081 RAPGEF4-001 protein_coding Homo_sapiens 0 4364
ENST00000397085 RAPGEF4-003 protein_coding Homo_sapiens 0 760
ENST00000397087 RAPGEF4-004 protein_coding Homo_sapiens 0 3738
ENST00000409036 RAPGEF4-011 protein_coding Homo_sapiens 0 3639
ENST00000459852 RAPGEF4-008 processed_transcript Homo_sapiens 0 625
ENST00000464976 RAPGEF4-009 processed_transcript Homo_sapiens 0 508
ENST00000466030 RAPGEF4-006 processed_transcript Homo_sapiens 0 610
ENST00000473003 RAPGEF4-013 processed_transcript Homo_sapiens 0 501
ENST00000473043 RAPGEF4-010 processed_transcript Homo_sapiens 0 1295
ENST00000473182 RAPGEF4-007 retained_intron Homo_sapiens 0 248
ENST00000484331 RAPGEF4-012 processed_transcript Homo_sapiens 0 564
ENST00000484645 RAPGEF4-002 retained_intron Homo_sapiens 0 409
ENST00000535187 RAPGEF4-201 protein_coding Homo_sapiens 0 3504
ENST00000538974 RAPGEF4-202 protein_coding Homo_sapiens 0 3502
ENST00000540783 RAPGEF4-203 protein_coding Homo_sapiens 0 3735

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