C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000102698 Rapgef4-003 ENSMUSG00000049044 10090 + 2:71981287-72256376 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainMuscleOvaryTestisENSMUST00000102698
Transcript ID Brain Muscle Ovary Testis
ENSMUST00000102698 91.311±0.00 0.147±0.00 4.271±0.00 0.895±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KA CIL_0004KA_0002 CGP 2:71873224-72257474
CIL_0003IJ CIL_0003IJ_0003 CGP 2:71981240-72442610

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005088 IDA Ras guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IEA membrane
GO:0017016 IPI Ras GTPase binding
GO:0017156 IDA calcium ion-dependent exocytosis
GO:0017157 IDA regulation of exocytosis
GO:0019933 IDA cAMP-mediated signaling
GO:0030073 IDA insulin secretion
GO:0030552 IDA cAMP binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0043547 IDA positive regulation of GTPase activity
GO:0045859 IEA regulation of protein kinase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000397081 RAPGEF4-001 protein_coding Homo_sapiens 0 3369
ENST00000397085 RAPGEF4-003 protein_coding Homo_sapiens 0 760
ENST00000397087 RAPGEF4-004 protein_coding Homo_sapiens 0 3369
ENST00000409036 RAPGEF4-011 protein_coding Homo_sapiens 0 2804
ENST00000459852 RAPGEF4-008 processed_transcript Homo_sapiens 0 625
ENST00000464976 RAPGEF4-009 processed_transcript Homo_sapiens 0 508
ENST00000466030 RAPGEF4-006 processed_transcript Homo_sapiens 0 525
ENST00000473003 RAPGEF4-013 processed_transcript Homo_sapiens 0 268
ENST00000473043 RAPGEF4-010 processed_transcript Homo_sapiens 0 1445
ENST00000473182 RAPGEF4-007 retained_intron Homo_sapiens 0 248
ENST00000484331 RAPGEF4-012 processed_transcript Homo_sapiens 0 564
ENST00000484645 RAPGEF4-002 retained_intron Homo_sapiens 0 279
ENST00000535187 RAPGEF4-201 protein_coding Homo_sapiens 0 3369
ENST00000538974 RAPGEF4-202 protein_coding Homo_sapiens 0 3518
ENST00000540783 RAPGEF4-203 protein_coding Homo_sapiens 0 3369

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