C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000327367 SMAD3-001 ENSG00000166949 9606 + 15:67065845-67195195 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000327367
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000327367 14.384±0.00 7.527±0.00 2.526±0.00 2.352±0.86 4.456±3.42 4.570±3.40 1.749±0.76 3.454±1.73 2.368±0.92 6.815±5.60 5.972±1.49 8.354±3.92 6.992±0.78 2.849±1.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008R9 CIL_0008R9_0001 VISTA 15:66606636-67207796
CIL_000471 CIL_000471_0002 CGP 15:66702228-67195195
CIL_0007L5 CIL_0007L5_0001 UCNEbase 15:66906943-67787880
CIL_00046Z CIL_00046Z_0002 CGP 15:67063763-67255195

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0000988 IDA protein binding transcription factor activity
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001501 IEA skeletal system development
GO:0001649 IEA osteoblast differentiation
GO:0001657 IEA ureteric bud development
GO:0001666 IMP response to hypoxia
GO:0001701 IEA in utero embryonic development
GO:0001707 IEA mesoderm formation
GO:0001756 IEA somitogenesis
GO:0001889 IEA liver development
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0001947 IEA heart looping
GO:0002076 IEA osteoblast development
GO:0002520 IEA immune system development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005160 IPI transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005518 IEA collagen binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005637 IDA nuclear inner membrane
GO:0005654 TAS nucleoplasm
GO:0005667 IDA:IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006810 IDA transport
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 IMP immune response
GO:0007050 IMP cell cycle arrest
GO:0007179 IDA:IEA transforming growth factor beta receptor signaling pathway
GO:0007183 IDA SMAD protein complex assembly
GO:0007369 IEA gastrulation
GO:0007492 IEA endoderm development
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008270 IDA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009880 IEA embryonic pattern specification
GO:0010467 TAS gene expression
GO:0010628 IDA positive regulation of gene expression
GO:0010694 IEA positive regulation of alkaline phosphatase activity
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0016202 IEA regulation of striated muscle tissue development
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 IDA evasion or tolerance of host defenses by virus
GO:0019899 IEA enzyme binding
GO:0019901 IPI protein kinase binding
GO:0019902 IPI phosphatase binding
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030308 IDA negative regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030501 IEA positive regulation of bone mineralization
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030618 IDA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030878 IEA thyroid gland development
GO:0031053 TAS primary miRNA processing
GO:0031490 IEA chromatin DNA binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032332 IEA positive regulation of chondrocyte differentiation
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0032916 IEA positive regulation of transforming growth factor beta3 production
GO:0032924 IMP activin receptor signaling pathway
GO:0033689 IEA negative regulation of osteoblast proliferation
GO:0035326 IC enhancer binding
GO:0035413 IMP positive regulation of catenin import into nucleus
GO:0035556 IDA intracellular signal transduction
GO:0038092 IMP nodal signaling pathway
GO:0042060 TAS wound healing
GO:0042110 IEA T cell activation
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042803 IPI protein homodimerization activity
GO:0042993 IDA positive regulation of transcription factor import into nucleus
GO:0043066 IEA negative regulation of apoptotic process
GO:0043130 IDA ubiquitin binding
GO:0043234 IEA protein complex
GO:0043235 IMP receptor complex
GO:0043425 IPI bHLH transcription factor binding
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045216 IMP cell-cell junction organization
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045930 IMP negative regulation of mitotic cell cycle
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0048340 IEA paraxial mesoderm morphogenesis
GO:0048589 IEA developmental growth
GO:0048617 IEA embryonic foregut morphogenesis
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0050678 IEA regulation of epithelial cell proliferation
GO:0050728 IEA negative regulation of inflammatory response
GO:0050776 IEA regulation of immune response
GO:0050821 IMP protein stabilization
GO:0050927 IEA positive regulation of positive chemotaxis
GO:0051098 IEA regulation of binding
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051894 IEA positive regulation of focal adhesion assembly
GO:0060039 IEA pericardium development
GO:0060290 IEA transdifferentiation
GO:0060395 IEA SMAD protein signal transduction
GO:0061045 IEA negative regulation of wound healing
GO:0070306 IEA lens fiber cell differentiation
GO:0070410 IPI co-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0071141 IDA SMAD protein complex
GO:0071144 IDA SMAD2-SMAD3 protein complex
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0097296 IEA activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901313 IDA positive regulation of gene expression involved in extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034973 Smad3-001 protein_coding Mus_musculus 0 1958
ENSDART00000043455 smad3b-001 protein_coding Danio_rerio 0 1007
ENSMUST00000154323 Smad3-002 protein_coding Mus_musculus 0 970
ENSDART00000044756 smad2-201 protein_coding Danio_rerio 0 761
ENSDART00000147653 smad2-002 protein_coding Danio_rerio 0 758
ENSDART00000121892 smad2-001 protein_coding Danio_rerio 0 758
ENSDART00000128579 smad2-202 protein_coding Danio_rerio 0 756
ENSMUST00000133108 Smad3-004 protein_coding Mus_musculus 0 579
ENSMUST00000137713 Smad3-005 protein_coding Mus_musculus 0 566
ENSMUST00000137065 Smad3-003 processed_transcript Mus_musculus 3e-35 156
ENSDART00000143608 smad2-004 protein_coding Danio_rerio 1e-34 154
ENSDART00000137430 smad2-003 protein_coding Danio_rerio 3e-30 139

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