C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000355771 ARHGEF4-009 ENSG00000136002 9606 + 2:131011683-131046189 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderLiverMuscleENST00000355771
Transcript ID Bladder Liver Muscle
ENST00000355771 0.053±0.00 0.122±0.08 0.133±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001J9 CIL_0001J9_0001 CGP 2:130755435-131047263
CIL_0001J8 CIL_0001J8_0001 CGP 2:130836916-131093460

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 IMP guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030676 IMP Rac guanyl-nucleotide exchange factor activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 IMP positive regulation of GTPase activity
GO:0046847 IMP filopodium assembly
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000159747 Arhgef4-004 protein_coding Mus_musculus 0 1929
ENSMUST00000047664 Arhgef4-001 protein_coding Mus_musculus 0 1816
ENSMUST00000162599 Arhgef4-005 protein_coding Mus_musculus 0 1219
ENSMUST00000162760 Arhgef4-002 retained_intron Mus_musculus 0 935
ENSMUST00000159021 Arhgef4-006 protein_coding Mus_musculus 0 835
ENSMUST00000160855 Arhgef4-003 nonsense_mediated_decay Mus_musculus 0 601
ENSMUST00000159059 Arhgef4-007 retained_intron Mus_musculus 0 601
ENSMUST00000022566 Spata13-201 protein_coding Mus_musculus 0 505
ENSMUST00000162945 Spata13-002 protein_coding Mus_musculus 0 505
ENSMUST00000160973 Spata13-001 protein_coding Mus_musculus 0 505
ENSMUST00000162131 Spata13-009 protein_coding Mus_musculus 0 211

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