C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136002 ARHGEF4 9606 + 2:130836916-131047263 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326016 ARHGEF4-001 130916651-131047253 protein_coding
  ENST00000355771 ARHGEF4-009 131011683-131046189 protein_coding
  ENST00000392953 ARHGEF4-201 130916651-131047263 protein_coding
  ENST00000409303 ARHGEF4-005 130930958-131046189 protein_coding
  ENST00000409359 ARHGEF4-003 130837455-130947230 protein_coding
  ENST00000428230 ARHGEF4-202 130916651-131047263 protein_coding
  ENST00000438985 ARHGEF4-004 130916965-131046708 protein_coding
  ENST00000439368 ARHGEF4-010 131034972-131041276 processed_transcript
  ENST00000490728 ARHGEF4-006 131039529-131047253 retained_intron
  ENST00000496764 ARHGEF4-007 131034928-131039670 processed_transcript
  ENST00000525092 ARHGEF4-014 131041511-131044534 retained_intron
  ENST00000525839 ARHGEF4-002 130917431-131047251 protein_coding
  ENST00000526381 ARHGEF4-008 130836916-130914485 processed_transcript
  ENST00000527365 ARHGEF4-013 131041313-131043670 retained_intron
  ENST00000528247 ARHGEF4-011 131035485-131040408 processed_transcript
  ENST00000532720 ARHGEF4-012 131041277-131045558 protein_coding
  ENST00000611048 ARHGEF4-203 130916651-131047263 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000326016ENST00000355771ENST00000409359ENST00000428230ENST00000439368ENST00000490728ENST00000496764ENST00000525092ENST00000525839ENST00000527365ENST00000528247ENST00000532720ENST00000611048
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000326016 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.733±0.58 N/A 1.481±0.00
ENST00000355771 N/A N/A 0.053±0.00 N/A N/A N/A N/A N/A 0.122±0.08 N/A 0.133±0.00 N/A N/A N/A
ENST00000409359 0.211±0.00 0.334±0.00 N/A 9.144±0.00 0.047±0.00 0.033±0.00 0.058±0.04 0.142±0.00 0.045±0.00 N/A N/A N/A N/A N/A
ENST00000428230 N/A N/A N/A N/A N/A N/A N/A 0.078±0.00 N/A N/A N/A N/A N/A N/A
ENST00000439368 N/A N/A N/A N/A N/A N/A 0.389±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000490728 N/A N/A N/A N/A 0.742±0.63 0.933±0.00 N/A N/A 0.059±0.00 0.667±0.00 0.199±0.00 2.539±0.84 N/A 4.448±0.09
ENST00000496764 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.141±0.00 N/A
ENST00000525092 N/A N/A N/A N/A 0.316±0.00 N/A N/A N/A 0.488±0.00 N/A 0.607±0.00 N/A N/A N/A
ENST00000525839 N/A N/A 0.064±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 2.866±0.00 N/A 3.089±0.00
ENST00000527365 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.314±0.00 N/A 0.168±0.00 N/A
ENST00000528247 N/A N/A N/A N/A 0.745±0.00 N/A N/A N/A 2.260±0.00 N/A N/A N/A N/A N/A
ENST00000532720 N/A 0.847±0.00 N/A N/A N/A N/A 0.074±0.00 0.377±0.00 N/A N/A 0.829±0.00 N/A 0.305±0.00 N/A
ENST00000611048 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.100±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001J9 CIL_0001J9_0001 CGP 2:130755435-131047263
CIL_0001J8 CIL_0001J8_0001 CGP 2:130836916-131093460

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IMP guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030676 IMP Rac guanyl-nucleotide exchange factor activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 IMP positive regulation of GTPase activity
GO:0046847 IMP filopodium assembly
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012914 arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 protein_coding Danio_rerio
ENSMUSG00000037509 Arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 protein_coding Mus_musculus

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