C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000395358 RAPGEF3-003 ENSG00000079337 9606 - 12:47744453-47758645 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastOvaryTestisENST00000395358
Transcript ID Breast Ovary Testis
ENST00000395358 7.730±6.08 1.586±0.00 2.573±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005YT CIL_0005YT_0001 CGP 12:47709734-47771040
CIL_0002OC CIL_0002OC_0001 CGP 12:47734672-47782753

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005886 TAS plasma membrane
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0007165 TAS signal transduction
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 TAS membrane
GO:0017034 IMP Rap guanyl-nucleotide exchange factor activity
GO:0019933 NAS cAMP-mediated signaling
GO:0030168 TAS platelet activation
GO:0030552 IEA cAMP binding
GO:0030822 NAS positive regulation of cAMP catabolic process
GO:0032486 IMP Rap protein signal transduction
GO:0032854 IMP positive regulation of Rap GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0044281 TAS small molecule metabolic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0045859 IEA regulation of protein kinase activity
GO:0050796 TAS regulation of insulin secretion
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0061028 IMP establishment of endothelial barrier
GO:0070062 IDA extracellular vesicular exosome
GO:0071320 IDA cellular response to cAMP
GO:2000249 IMP regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000123397 Rapgef3-004 retained_intron Mus_musculus 0 1792
ENSMUST00000128775 Rapgef3-003 protein_coding Mus_musculus 0 1792
ENSMUST00000129223 Rapgef3-001 protein_coding Mus_musculus 0 1792
ENSMUST00000126854 Rapgef3-005 protein_coding Mus_musculus 0 1792
ENSMUST00000177352 Rapgef3-007 protein_coding Mus_musculus 0 1749
ENSMUST00000175894 Rapgef3-018 nonsense_mediated_decay Mus_musculus 0 1136
ENSMUST00000149419 Rapgef3-009 nonsense_mediated_decay Mus_musculus 0 721
ENSMUST00000146620 Rapgef3-008 protein_coding Mus_musculus 0 562
ENSMUST00000153464 Rapgef3-010 processed_transcript Mus_musculus 0 553
ENSMUST00000153241 Rapgef3-012 processed_transcript Mus_musculus 0 446
ENSMUST00000142196 Rapgef3-011 retained_intron Mus_musculus 0 353

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