C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: LIM domain and actin binding 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000050405 LIMA1 9606 - 12:50175788-50283546 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000341247 LIMA1-003 50175788-50283546 protein_coding
  ENST00000394943 LIMA1-001 50175788-50283506 protein_coding
  ENST00000547825 LIMA1-007 50175788-50202112 protein_coding
  ENST00000549064 LIMA1-014 50177698-50182179 retained_intron
  ENST00000550592 LIMA1-008 50222318-50249893 protein_coding
  ENST00000550611 LIMA1-010 50222167-50224481 processed_transcript
  ENST00000551486 LIMA1-012 50204344-50222165 retained_intron
  ENST00000551691 LIMA1-009 50222260-50283484 protein_coding
  ENST00000552008 LIMA1-011 50192452-50220556 processed_transcript
  ENST00000552045 LIMA1-016 50195618-50200892 retained_intron
  ENST00000552338 LIMA1-015 50177774-50196047 processed_transcript
  ENST00000552491 LIMA1-017 50175788-50200847 protein_coding
  ENST00000552720 LIMA1-005 50177006-50283456 nonsense_mediated_decay
  ENST00000552783 LIMA1-002 50175790-50222705 protein_coding
  ENST00000552823 LIMA1-006 50175788-50222348 protein_coding
  ENST00000552909 LIMA1-004 50176885-50222356 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000341247ENST00000394943ENST00000547825ENST00000552491ENST00000552720ENST00000552783ENST00000552823ENST00000552909
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000341247 3.780±0.00 N/A N/A 0.319±0.00 5.988±3.17 9.512±3.30 2.231±0.00 3.465±3.02 1.810±0.00 5.041±2.08 N/A 6.879±2.83 8.511±3.95 4.136±1.45
ENST00000394943 N/A 3.347±0.00 N/A 0.799±0.00 N/A N/A N/A N/A 0.740±0.00 N/A 0.798±0.00 6.554±0.00 3.113±0.00 N/A
ENST00000547825 2.559±0.00 3.041±0.00 N/A 0.515±0.17 7.182±0.00 N/A 0.838±0.00 N/A 3.083±0.00 3.356±0.00 0.393±0.00 2.187±0.12 N/A N/A
ENST00000552491 7.937±0.00 4.996±0.00 1.647±0.00 1.088±0.00 13.733±0.00 5.386±0.00 N/A 9.612±0.00 N/A 10.923±0.00 N/A 11.284±0.00 5.194±1.25 4.877±0.00
ENST00000552720 N/A N/A 2.674±0.00 N/A 6.131±0.00 8.289±0.00 0.320±0.00 N/A 3.489±0.00 3.465±0.00 N/A 6.121±0.00 N/A N/A
ENST00000552783 3.175±0.00 2.588±0.00 N/A 0.656±0.18 9.565±1.77 4.639±0.37 0.789±0.00 0.509±0.00 7.713±0.00 9.176±0.00 0.170±0.00 4.252±1.10 3.884±0.71 N/A
ENST00000552823 N/A N/A N/A N/A N/A N/A 1.354±0.00 4.446±0.00 1.407±0.00 N/A 0.457±0.00 4.781±1.66 8.302±2.97 3.114±0.63
ENST00000552909 N/A N/A N/A 1.255±0.00 N/A N/A 0.514±0.00 N/A N/A N/A 0.440±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PE CIL_0008PE_0001 VISTA 12:49905565-50507504
CIL_0008CC CIL_0008CC_0001 VISTA 12:49906068-50507455
CIL_0000LJ CIL_0000LJ_0001 CGP 12:50129306-50283546
CIL_00051T CIL_00051T_0001 CGP 12:50175788-50396622

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001725 IDA stress fiber
GO:0003785 IDA actin monomer binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0008270 IEA zinc ion binding
GO:0015629 IDA actin cytoskeleton
GO:0030835 IEA:IDA negative regulation of actin filament depolymerization
GO:0031529 IDA ruffle organization
GO:0051015 IEA:IDA actin filament binding
GO:0051017 IEA:IDA actin filament bundle assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074020 lima1 LIM domain and actin binding 1 protein_coding Danio_rerio
ENSDARG00000076009 LIMA1 (2 of 2) LIM domain and actin binding 1 protein_coding Danio_rerio
ENSMUSG00000023022 Lima1 LIM domain and actin binding 1 protein_coding Mus_musculus

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