C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091409 ITGA6 9606 + 2:172427354-172506282 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264107 ITGA6-001 172427555-172506230 protein_coding
  ENST00000409080 ITGA6-004 172427789-172506282 protein_coding
  ENST00000409532 ITGA6-003 172427418-172504534 protein_coding
  ENST00000412899 ITGA6-002 172427354-172474977 protein_coding
  ENST00000416789 ITGA6-006 172487962-172504328 protein_coding
  ENST00000442250 ITGA6-010 172427789-172504252 protein_coding
  ENST00000458358 ITGA6-011 172427789-172504252 protein_coding
  ENST00000469534 ITGA6-007 172488005-172489928 retained_intron
  ENST00000470259 ITGA6-008 172490792-172491254 retained_intron
  ENST00000475302 ITGA6-009 172490929-172501818 retained_intron
  ENST00000497107 ITGA6-005 172468998-172474112 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264107ENST00000409080ENST00000409532ENST00000416789ENST00000442250ENST00000458358ENST00000497107
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264107 27.218±0.00 9.432±0.00 2.911±0.00 1.964±0.03 11.576±6.60 12.148±0.00 6.287±0.33 N/A 4.945±0.00 6.052±3.19 3.094±0.00 15.475±9.91 17.055±10.60 5.009±0.00
ENST00000409080 32.748±0.00 5.360±0.00 3.957±0.00 6.485±0.00 8.966±0.61 15.044±1.97 5.023±0.00 12.187±0.00 2.484±0.61 7.892±0.14 N/A 8.250±4.29 22.508±6.64 13.498±0.00
ENST00000409532 N/A N/A N/A N/A N/A N/A N/A 1.563±0.00 N/A N/A 3.302±0.00 12.666±0.00 N/A N/A
ENST00000416789 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.834±0.00
ENST00000442250 N/A N/A N/A N/A N/A N/A N/A 1.944±0.00 N/A 9.116±0.00 N/A N/A N/A N/A
ENST00000458358 N/A N/A N/A N/A 6.247±0.00 13.765±0.00 6.330±0.00 N/A 8.484±0.00 N/A N/A N/A N/A N/A
ENST00000497107 N/A N/A 44.079±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003IK CIL_0003IK_0002 CGP 2:172099439-172506282
CIL_0004K8 CIL_0004K8_0001 CGP 2:172427354-172608669

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005604 IEA basement membrane
GO:0005886 IDA plasma membrane
GO:0005913 IEA cell-cell adherens junction
GO:0005925 IDA focal adhesion
GO:0007044 TAS cell-substrate junction assembly
GO:0007160 IEA cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008305 IEA integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009925 IEA basal plasma membrane
GO:0009986 IDA cell surface
GO:0010668 IEP ectodermal cell differentiation
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0016323 IEA basolateral plasma membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030056 IEA hemidesmosome
GO:0030175 IEA filopodium
GO:0030198 TAS extracellular matrix organization
GO:0031581 TAS hemidesmosome assembly
GO:0031589 IMP cell-substrate adhesion
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032403 IEA protein complex binding
GO:0033627 IEA cell adhesion mediated by integrin
GO:0034329 TAS cell junction assembly
GO:0034676 IEA integrin alpha6-beta4 complex
GO:0035878 IMP nail development
GO:0042327 IMP positive regulation of phosphorylation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0043065 IGI positive regulation of apoptotic process
GO:0043236 IEA laminin binding
GO:0043588 IMP skin development
GO:0045178 IEA basal part of cell
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046847 IEA filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048565 IMP digestive tract development
GO:0050873 IEA brown fat cell differentiation
GO:0050900 TAS leukocyte migration
GO:0071407 IEA cellular response to organic cyclic compound
GO:0072001 IMP renal system development
GO:0097186 IMP amelogenesis
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042282 itga6a integrin, alpha 6a protein_coding Danio_rerio
ENSDARG00000056018 itga6l integrin, alpha 6, like protein_coding Danio_rerio
ENSDARG00000069946 itga6b integrin, alpha 6b protein_coding Danio_rerio
ENSMUSG00000027111 Itga6 integrin alpha 6 protein_coding Mus_musculus

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