C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127616 SMARCA4 9606 + 19:10961001-11065395 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344626 SMARCA4-001 10961001-11062059 protein_coding
  ENST00000413806 SMARCA4-201 10984152-11062282 protein_coding
  ENST00000429416 SMARCA4-007 10961001-11062282 protein_coding
  ENST00000444061 SMARCA4-003 10961110-11061816 protein_coding
  ENST00000450717 SMARCA4-202 10984152-11062282 protein_coding
  ENST00000538456 SMARCA4-006 11033436-11041560 processed_transcript
  ENST00000541122 SMARCA4-005 10961081-11061816 protein_coding
  ENST00000585799 SMARCA4-011 11020581-11062276 retained_intron
  ENST00000586122 SMARCA4-016 11018312-11023588 processed_transcript
  ENST00000586892 SMARCA4-013 11033082-11034146 retained_intron
  ENST00000586921 SMARCA4-014 11060461-11062269 processed_transcript
  ENST00000586985 SMARCA4-015 11058835-11065395 protein_coding
  ENST00000587988 SMARCA4-012 11018870-11023561 retained_intron
  ENST00000589677 SMARCA4-004 10961105-11061816 protein_coding
  ENST00000590574 SMARCA4-002 10961321-11061816 protein_coding
  ENST00000591545 SMARCA4-009 10984278-11032666 retained_intron
  ENST00000591595 SMARCA4-010 11019014-11062276 retained_intron
  ENST00000592158 SMARCA4-018 11030813-11041466 protein_coding
  ENST00000592604 SMARCA4-008 11012762-11061989 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344626ENST00000429416ENST00000444061ENST00000450717ENST00000538456ENST00000585799ENST00000586921ENST00000590574ENST00000591545ENST00000591595ENST00000592604
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344626 10.862±0.00 6.423±0.00 1.791±0.00 6.590±5.69 2.203±1.19 4.419±0.00 3.884±0.00 N/A 0.575±0.00 3.653±0.00 8.669±0.00 13.375±9.53 10.673±7.74 20.880±5.67
ENST00000429416 N/A N/A N/A N/A N/A N/A 0.507±0.00 N/A N/A 3.296±0.00 N/A N/A N/A N/A
ENST00000444061 6.389±0.00 7.412±0.00 1.360±0.00 12.243±0.00 4.446±1.23 2.900±0.26 2.389±2.13 7.684±0.00 N/A 3.969±1.43 3.278±2.61 9.163±5.43 9.895±5.36 17.482±2.60
ENST00000450717 N/A N/A N/A N/A N/A N/A 2.188±0.00 N/A 2.373±0.00 N/A N/A 5.776±4.45 N/A 14.446±0.00
ENST00000538456 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 71.046±0.00 N/A N/A
ENST00000585799 N/A N/A N/A N/A N/A N/A 0.434±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000586921 N/A N/A N/A N/A N/A N/A N/A 29.852±0.00 N/A N/A N/A N/A N/A N/A
ENST00000590574 N/A N/A N/A 1.060±0.00 N/A N/A N/A 0.801±0.00 N/A N/A N/A N/A N/A N/A
ENST00000591545 N/A N/A N/A N/A N/A N/A N/A N/A 0.720±0.00 N/A N/A N/A N/A N/A
ENST00000591595 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.485±0.00 N/A N/A
ENST00000592604 9.927±0.00 N/A N/A N/A 3.231±0.90 2.967±0.00 N/A 8.037±0.00 3.223±0.00 5.402±3.29 N/A N/A 5.216±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002S7 CIL_0002S7_0001 CGP 19:10928733-11065395
CIL_00058P CIL_00058P_0003 CGP 19:10961001-11133816

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000792 IEA heterochromatin
GO:0000902 IEA cell morphogenesis
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001570 IEA vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0001832 IEA blastocyst growth
GO:0001835 IEA blastocyst hatching
GO:0001889 IEA liver development
GO:0002039 IPI p53 binding
GO:0003407 IEP neural retina development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003713 IMP transcription coactivator activity
GO:0003714 IDA transcription corepressor activity
GO:0004386 IEA helicase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005634 IDA:IEA nucleus
GO:0005719 IEA nuclear euchromatin
GO:0005726 IEA perichromatin fibrils
GO:0005730 IDA nucleolus
GO:0006200 IGI ATP catabolic process
GO:0006337 IDA nucleosome disassembly
GO:0006338 IDA chromatin remodeling
GO:0006346 IEA methylation-dependent chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 NAS regulation of transcription from RNA polymerase II promoter
GO:0007070 TAS negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007399 IEA nervous system development
GO:0007403 IEA glial cell fate determination
GO:0007507 IEA heart development
GO:0008094 IGI DNA-dependent ATPase activity
GO:0008134 IEA transcription factor binding
GO:0010424 IEA DNA methylation on cytosine within a CG sequence
GO:0016020 IDA membrane
GO:0016514 IDA SWI/SNF complex
GO:0016817 IEA hydrolase activity, acting on acid anhydrides
GO:0016818 IEA hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0019827 IEA stem cell maintenance
GO:0022008 IEA neurogenesis
GO:0030198 IEA extracellular matrix organization
GO:0030216 IEA keratinocyte differentiation
GO:0030308 IMP negative regulation of cell growth
GO:0030900 IEA forebrain development
GO:0030902 IEA hindbrain development
GO:0030957 IPI Tat protein binding
GO:0031492 IDA nucleosomal DNA binding
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035887 IEA aortic smooth muscle cell differentiation
GO:0042393 IEA histone binding
GO:0043044 IDA ATP-dependent chromatin remodeling
GO:0043234 IDA protein complex
GO:0043388 IEA positive regulation of DNA binding
GO:0043923 IMP positive regulation by host of viral transcription
GO:0043966 IEA histone H3 acetylation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0047485 IPI protein N-terminus binding
GO:0048562 IEA embryonic organ morphogenesis
GO:0048730 IEA epidermis morphogenesis
GO:0050681 IPI androgen receptor binding
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060318 IEA definitive erythrocyte differentiation
GO:0060347 IEA heart trabecula formation
GO:0060766 IMP negative regulation of androgen receptor signaling pathway
GO:0070307 IEA lens fiber cell development
GO:0070577 IDA lysine-acetylated histone binding
GO:0071564 ISS npBAF complex
GO:0071565 ISS nBAF complex
GO:2000134 TAS negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008350 SMARCA4 (1 of 2) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 protein_coding Danio_rerio
ENSDARG00000077226 smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 protein_coding Danio_rerio
ENSMUSG00000032187 Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 protein_coding Mus_musculus

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