C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tryptophan hydroxylase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129167 TPH1 9606 - 11:18017564-18042426 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250018 TPH1-001 18017564-18041325 protein_coding
  ENST00000417164 TPH1-002 18020991-18040762 nonsense_mediated_decay
  ENST00000525406 TPH1-003 18021077-18023169 processed_transcript
  ENST00000528338 TPH1-004 18029515-18042426 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonLungOvaryTestisENST00000250018
Transcript ID Bladder Breast Colon Lung Ovary Testis
ENST00000250018 0.190±0.00 0.444±0.00 2.511±0.00 0.193±0.00 0.527±0.00 0.441±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001IE CIL_0001IE_0002 CGP 11:17788048-18042426
CIL_00041A CIL_00041A_0002 CGP 11:18017564-18106091

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004510 IEA tryptophan 5-monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005829 TAS cytosol
GO:0007623 IEA circadian rhythm
GO:0008152 IEA metabolic process
GO:0009072 IEA aromatic amino acid family metabolic process
GO:0016597 IEA amino acid binding
GO:0016714 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0030279 IEA negative regulation of ossification
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035902 IEA response to immobilization stress
GO:0042427 IEA serotonin biosynthetic process
GO:0043005 IEA neuron projection
GO:0044281 TAS small molecule metabolic process
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0046219 TAS indolalkylamine biosynthetic process
GO:0046849 IEA bone remodeling
GO:0055114 IEA oxidation-reduction process
GO:0060749 IEA mammary gland alveolus development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029432 tph1a tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a protein_coding Danio_rerio
ENSDARG00000036082 tph1b tryptophan hydroxylase 1b protein_coding Danio_rerio
ENSMUSG00000040046 Tph1 tryptophan hydroxylase 1 protein_coding Mus_musculus

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