C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tryptophan hydroxylase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040046 Tph1 10090 - 7:46647130-46672537 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049298 Tph1-002 46647161-46672537 protein_coding
  ENSMUST00000107669 Tph1-001 46647130-46667377 protein_coding
  ENSMUST00000110264 Tph1-007 46649741-46651419 retained_intron
  ENSMUST00000163468 Tph1-004 46660020-46662315 retained_intron
  ENSMUST00000168335 Tph1-003 46660338-46667343 protein_coding
  ENSMUST00000170045 Tph1-008 46656862-46660668 retained_intron
  ENSMUST00000170251 Tph1-005 46647426-46665301 nonsense_mediated_decay
  ENSMUST00000172386 Tph1-006 46647426-46665288 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049298ENSMUST00000107669ENSMUST00000168335ENSMUST00000170045ENSMUST00000170251ENSMUST00000172386
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049298 N/A N/A N/A 0.067±0.00 N/A N/A N/A N/A N/A N/A 0.641±0.18 0.027±0.00 N/A N/A
ENSMUST00000107669 0.046±0.03 0.058±0.00 0.009±0.00 0.096±0.01 0.398±0.27 2.684±0.77 N/A 0.019±0.00 0.016±0.00 N/A 0.414±0.19 0.077±0.04 0.528±0.58 N/A
ENSMUST00000168335 N/A N/A N/A N/A N/A N/A 0.120±0.10 N/A N/A 0.232±0.00 N/A 0.072±0.00 1.669±0.00 0.078±0.00
ENSMUST00000170045 N/A N/A N/A N/A 0.388±0.00 N/A 0.089±0.00 0.096±0.00 N/A N/A N/A 0.740±0.00 N/A 0.205±0.00
ENSMUST00000170251 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.060±0.00
ENSMUST00000172386 N/A N/A 0.043±0.01 N/A 0.063±0.00 N/A 0.045±0.00 N/A N/A N/A N/A 0.122±0.03 0.024±0.00 0.032±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001IE CIL_0001IE_0003 CGP 7:46443168-46672537
CIL_00041A CIL_00041A_0003 CGP 7:46647130-46710680

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004510 IDA tryptophan 5-monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0007623 IEA circadian rhythm
GO:0009072 IEA aromatic amino acid family metabolic process
GO:0016597 IEA amino acid binding
GO:0030279 IEA negative regulation of ossification
GO:0035902 IEA response to immobilization stress
GO:0042427 IEA serotonin biosynthetic process
GO:0043005 IEA neuron projection
GO:0045600 IMP positive regulation of fat cell differentiation
GO:0046849 IGI bone remodeling
GO:0055114 IEA oxidation-reduction process
GO:0060749 IMP mammary gland alveolus development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029432 tph1a tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a protein_coding Danio_rerio
ENSDARG00000036082 tph1b tryptophan hydroxylase 1b protein_coding Danio_rerio
ENSG00000129167 TPH1 tryptophan hydroxylase 1 protein_coding Homo_sapiens

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