C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000379608 TFAP2A-005 ENSG00000137203 9606 - 6:10397915-10412374 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderLungOvaryPlacentaTestisENST00000379608
Transcript ID Adipose Bladder Lung Ovary Placenta Testis
ENST00000379608 0.058±0.00 0.406±0.00 0.147±0.00 0.404±0.00 9.734±3.08 0.631±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007NC CIL_0007NC_0001 UCNEbase 6:8153140-10408054
CIL_00097A CIL_00097A_0001 VISTA 6:10093642-10694839
CIL_00086X CIL_00086X_0001 VISTA 6:10107199-10709812
CIL_000382 CIL_000382_0001 CGP 6:10393186-10629368

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001822 IMP kidney development
GO:0003404 ISS optic vesicle morphogenesis
GO:0003409 ISS optic cup structural organization
GO:0003682 ISS chromatin binding
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005813 IDA centrosome
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007605 IMP sensory perception of sound
GO:0008285 IDA negative regulation of cell proliferation
GO:0010628 ISS positive regulation of gene expression
GO:0010842 IEP retina layer formation
GO:0010944 IMP negative regulation of transcription by competitive promoter binding
GO:0021559 ISS trigeminal nerve development
GO:0021623 ISS oculomotor nerve formation
GO:0030501 IDA positive regulation of bone mineralization
GO:0035115 ISS embryonic forelimb morphogenesis
GO:0042472 IMP inner ear morphogenesis
GO:0042803 TAS protein homodimerization activity
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045595 IDA regulation of cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IDA protein dimerization activity
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0060021 IMP palate development
GO:0060349 ISS bone morphogenesis
GO:0061029 ISS eyelid development in camera-type eye
GO:0070172 IDA positive regulation of tooth mineralization
GO:0071281 IDA cellular response to iron ion
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000021787 Tfap2a-201 protein_coding Mus_musculus 0 2246
ENSMUST00000110193 Tfap2a-202 protein_coding Mus_musculus 0 2145
ENSMUST00000064976 Tfap2b-003 protein_coding Mus_musculus 0 296
ENSMUST00000187754 Tfap2b-002 protein_coding Mus_musculus 0 296
ENSMUST00000027059 Tfap2b-001 protein_coding Mus_musculus 0 296
ENSDART00000082346 tfap2a-201 protein_coding Danio_rerio 1e-21 110

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