C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000379604 TFAP2A-201 ENSG00000137203 9606 - 6:10396683-10415237 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastKidneyLiverOvaryPlacentaENST00000379604
Transcript ID Adipose Brain Breast Kidney Liver Ovary Placenta
ENST00000379604 0.031±0.00 0.076±0.00 0.319±0.26 2.454±0.00 0.003±0.00 0.347±0.00 13.644±7.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007NC CIL_0007NC_0001 UCNEbase 6:8153140-10408054
CIL_00097A CIL_00097A_0001 VISTA 6:10093642-10694839
CIL_00086X CIL_00086X_0001 VISTA 6:10107199-10709812
CIL_000382 CIL_000382_0001 CGP 6:10393186-10629368

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001105 IEA RNA polymerase II transcription coactivator activity
GO:0001106 IEA RNA polymerase II transcription corepressor activity
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001822 IMP kidney development
GO:0001843 IEA neural tube closure
GO:0002089 IEA lens morphogenesis in camera-type eye
GO:0003151 IEA outflow tract morphogenesis
GO:0003334 IEA keratinocyte development
GO:0003404 ISS optic vesicle morphogenesis
GO:0003409 ISS optic cup structural organization
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005813 IDA centrosome
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007399 IEA nervous system development
GO:0007423 IEA sensory organ development
GO:0007605 IMP sensory perception of sound
GO:0008285 IDA negative regulation of cell proliferation
GO:0009880 IEA embryonic pattern specification
GO:0010172 IEA embryonic body morphogenesis
GO:0010628 ISS positive regulation of gene expression
GO:0010842 IEP retina layer formation
GO:0010944 IMP negative regulation of transcription by competitive promoter binding
GO:0014032 IEA neural crest cell development
GO:0021506 IEA anterior neuropore closure
GO:0021559 ISS trigeminal nerve development
GO:0021623 ISS oculomotor nerve formation
GO:0021884 IEA forebrain neuron development
GO:0030335 IEA positive regulation of cell migration
GO:0030501 IDA positive regulation of bone mineralization
GO:0035115 ISS embryonic forelimb morphogenesis
GO:0035136 IEA forelimb morphogenesis
GO:0042059 IEA negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 IMP inner ear morphogenesis
GO:0042803 TAS protein homodimerization activity
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043588 IEA skin development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045595 IDA regulation of cell differentiation
GO:0045664 IEA regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IDA protein dimerization activity
GO:0048485 IEA sympathetic nervous system development
GO:0048596 IEA embryonic camera-type eye morphogenesis
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0048730 IEA epidermis morphogenesis
GO:0060021 IMP palate development
GO:0060235 IEA lens induction in camera-type eye
GO:0060325 IEA face morphogenesis
GO:0060349 ISS bone morphogenesis
GO:0061029 ISS eyelid development in camera-type eye
GO:0061303 IEA cornea development in camera-type eye
GO:0070172 IDA positive regulation of tooth mineralization
GO:0071281 IDA cellular response to iron ion
GO:0071711 IEA basement membrane organization
GO:0072210 IEA metanephric nephron development
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110193 Tfap2a-202 protein_coding Mus_musculus 0 2892
ENSMUST00000021787 Tfap2a-201 protein_coding Mus_musculus 0 2693
ENSMUST00000064976 Tfap2b-003 protein_coding Mus_musculus 0 296
ENSMUST00000187754 Tfap2b-002 protein_coding Mus_musculus 0 296
ENSMUST00000027059 Tfap2b-001 protein_coding Mus_musculus 0 296
ENSDART00000082346 tfap2a-201 protein_coding Danio_rerio 0 202
ENSDART00000082349 tfap2a-202 protein_coding Danio_rerio 0 202
ENSDART00000082351 tfap2a-203 protein_coding Danio_rerio 0 202

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