C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000174437 ATP2A2 9606 + 12:110280756-110351093 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308664 ATP2A2-001 110281116-110351090 protein_coding
  ENST00000313432 ATP2A2-011 110345437-110351093 retained_intron
  ENST00000377685 ATP2A2-002 110281297-110351057 nonsense_mediated_decay
  ENST00000539276 ATP2A2-003 110281681-110347326 protein_coding
  ENST00000547050 ATP2A2-008 110325801-110332632 retained_intron
  ENST00000547792 ATP2A2-010 110343256-110345247 retained_intron
  ENST00000548169 ATP2A2-006 110292049-110346621 protein_coding
  ENST00000549840 ATP2A2-007 110327687-110332143 processed_transcript
  ENST00000550248 ATP2A2-005 110295991-110323072 processed_transcript
  ENST00000550262 ATP2A2-009 110329399-110334291 retained_intron
  ENST00000552636 ATP2A2-004 110280756-110296712 protein_coding
  ENST00000553144 ATP2A2-012 110346201-110350373 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308664ENST00000313432ENST00000377685ENST00000539276ENST00000548169
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308664 7.323±0.00 9.110±0.00 N/A N/A 29.299±0.00 11.597±0.00 322.690±281.03 N/A 4.920±0.00 8.610±0.00 300.412±84.85 15.407±0.00 N/A 15.925±0.00
ENST00000313432 N/A 4.979±0.00 N/A N/A N/A N/A N/A N/A 8.927±0.00 12.840±0.00 N/A 10.131±1.70 N/A 16.055±0.00
ENST00000377685 N/A N/A 1.304±0.00 N/A 3.331±0.00 N/A N/A 2.873±0.00 N/A N/A N/A 3.235±0.00 N/A N/A
ENST00000539276 10.335±0.00 7.371±0.00 4.249±0.00 15.890±0.00 10.932±0.00 8.766±3.25 N/A 11.531±3.19 17.647±2.49 15.001±3.01 N/A 18.499±10.88 19.061±0.83 38.839±10.71
ENST00000548169 N/A 7.930±0.00 N/A N/A 5.474±0.00 5.719±0.00 N/A N/A N/A 17.711±0.00 N/A 27.350±0.00 12.708±0.00 42.060±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001QG CIL_0001QG_0002 CGP 12:110124335-110351093
CIL_0001QF CIL_0001QF_0002 CGP 12:110280756-110403730

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0002026 IEA regulation of the force of heart contraction
GO:0005388 TAS:IEA calcium-transporting ATPase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006810 TAS transport
GO:0006816 IEA calcium ion transport
GO:0006874 TAS cellular calcium ion homeostasis
GO:0006984 IEA ER-nucleus signaling pathway
GO:0007155 TAS cell adhesion
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008152 IEA metabolic process
GO:0008544 TAS epidermis development
GO:0010460 TAS positive regulation of heart rate
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016529 IDA sarcoplasmic reticulum
GO:0019899 IPI enzyme binding
GO:0031095 TAS platelet dense tubular network membrane
GO:0033017 TAS sarcoplasmic reticulum membrane
GO:0034220 TAS ion transmembrane transport
GO:0043231 TAS intracellular membrane-bounded organelle
GO:0044548 IPI S100 protein binding
GO:0045822 IEA negative regulation of heart contraction
GO:0046872 IEA metal ion binding
GO:0055085 TAS transmembrane transport
GO:0055119 TAS relaxation of cardiac muscle
GO:0070296 TAS sarcoplasmic reticulum calcium ion transport
GO:0070588 IEA calcium ion transmembrane transport
GO:0086036 TAS regulation of cardiac muscle cell membrane potential
GO:0086039 TAS calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005122 atp2a2b ATPase, Ca++ transporting, cardiac muscle, slow twitch 2b protein_coding Danio_rerio
ENSDARG00000029439 atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a protein_coding Danio_rerio
ENSMUSG00000029467 Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 protein_coding Mus_musculus

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