C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196189 SEMA4A 9606 + 1:156147366-156177752 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355014 SEMA4A-002 156150019-156177744 protein_coding
  ENST00000368282 SEMA4A-003 156154371-156177752 protein_coding
  ENST00000368284 SEMA4A-004 156153578-156177743 protein_coding
  ENST00000368285 SEMA4A-001 156153527-156177744 protein_coding
  ENST00000368286 SEMA4A-201 156153585-156177743 protein_coding
  ENST00000414683 SEMA4A-007 156149723-156161493 protein_coding
  ENST00000435124 SEMA4A-015 156147366-156161498 protein_coding
  ENST00000438830 SEMA4A-013 156153607-156161028 protein_coding
  ENST00000462892 SEMA4A-011 156161227-156175647 retained_intron
  ENST00000466698 SEMA4A-009 156160544-156161669 retained_intron
  ENST00000469065 SEMA4A-010 156160950-156163298 retained_intron
  ENST00000470306 SEMA4A-005 156154877-156159031 retained_intron
  ENST00000484155 SEMA4A-012 156175333-156176656 processed_transcript
  ENST00000485575 SEMA4A-008 156150203-156156574 processed_transcript
  ENST00000487358 SEMA4A-006 156156425-156175232 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355014ENST00000368282ENST00000368284ENST00000368285ENST00000368286ENST00000435124ENST00000438830ENST00000462892ENST00000470306ENST00000485575ENST00000487358
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355014 0.804±0.00 1.808±0.00 N/A 3.092±0.60 3.304±0.00 1.362±0.00 0.066±0.00 6.204±0.00 0.734±0.00 3.345±2.21 N/A 0.605±0.00 0.574±0.15 2.044±0.00
ENST00000368282 N/A N/A N/A 0.778±0.00 0.952±0.00 N/A N/A N/A N/A N/A N/A 1.167±0.56 N/A 0.762±0.00
ENST00000368284 N/A N/A N/A N/A N/A N/A 0.069±0.00 N/A 0.403±0.00 N/A N/A N/A N/A N/A
ENST00000368285 N/A N/A 0.162±0.00 N/A N/A N/A N/A 4.470±0.00 N/A N/A N/A 2.258±0.62 0.371±0.00 N/A
ENST00000368286 N/A 1.084±0.00 N/A 0.728±0.00 N/A N/A N/A 1.659±0.00 N/A N/A N/A 2.077±0.68 N/A 1.312±0.00
ENST00000435124 N/A N/A N/A 3.023±0.00 N/A 0.759±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000438830 N/A N/A N/A N/A N/A N/A 0.165±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000462892 N/A N/A N/A N/A N/A N/A N/A 0.201±0.00 N/A N/A N/A N/A N/A N/A
ENST00000470306 N/A N/A 0.409±0.00 N/A 0.567±0.00 N/A N/A N/A 0.487±0.00 0.773±0.00 0.027±0.00 0.525±0.00 N/A N/A
ENST00000485575 N/A N/A N/A N/A N/A N/A N/A 0.412±0.00 N/A N/A N/A N/A N/A N/A
ENST00000487358 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.328±0.00 0.971±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000898 CIL_000898_0001 VISTA 1:155789635-156392759
CIL_0008P5 CIL_0008P5_0001 VISTA 1:155795688-156399252

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0002292 IEA T cell differentiation involved in immune response
GO:0004872 IEA receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005886 TAS plasma membrane
GO:0007275 IEA multicellular organismal development
GO:0007409 IEA axonogenesis
GO:0007411 TAS axon guidance
GO:0008360 IEA regulation of cell shape
GO:0010594 IEA regulation of endothelial cell migration
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016525 IEA negative regulation of angiogenesis
GO:0045063 IEA T-helper 1 cell differentiation
GO:0071526 IEA semaphorin-plexin signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062352 sema4ab sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab protein_coding Danio_rerio
ENSDARG00000077103 sema4aa sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Aa protein_coding Danio_rerio
ENSMUSG00000028064 Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A protein_coding Mus_musculus

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