C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage gated, type VIII, alpha subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196876 SCN8A 9606 + 12:51590266-51812864 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354534 SCN8A-001 51591236-51812864 protein_coding
  ENST00000355133 SCN8A-005 51662818-51807429 protein_coding
  ENST00000545061 SCN8A-201 51591236-51812864 protein_coding
  ENST00000546961 SCN8A-002 51590266-51662820 processed_transcript
  ENST00000548086 SCN8A-006 51774240-51786771 processed_transcript
  ENST00000550891 SCN8A-003 51590926-51766251 protein_coding
  ENST00000551216 SCN8A-004 51686423-51745948 protein_coding
  ENST00000599343 SCN8A-202 51591236-51812864 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000354534ENST00000355133ENST00000545061ENST00000550891ENST00000551216ENST00000599343
Transcript ID Adipose Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000354534 N/A N/A 5.685±3.39 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000355133 N/A N/A N/A N/A 0.365±0.00 N/A N/A N/A N/A N/A N/A 0.598±0.00
ENST00000545061 0.024±0.00 N/A N/A 0.061±0.00 0.234±0.05 0.010±0.00 0.055±0.02 0.052±0.00 0.014±0.00 0.085±0.02 0.036±0.01 0.573±0.00
ENST00000550891 N/A 0.755±0.00 N/A N/A N/A N/A N/A N/A N/A 0.240±0.00 N/A N/A
ENST00000551216 N/A N/A 21.950±0.00 0.334±0.00 0.643±0.00 N/A N/A 0.179±0.00 N/A 0.280±0.12 N/A N/A
ENST00000599343 N/A N/A 3.246±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006JW CIL_0006JW_0001 CGP 12:51391317-51812864

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IC:IEA voltage-gated sodium channel complex
GO:0005216 IEA ion channel activity
GO:0005248 IDA:IEA voltage-gated sodium channel activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005886 IBA plasma membrane
GO:0006811 IEA ion transport
GO:0006814 NAS:IEA sodium ion transport
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0007422 ISS peripheral nervous system development
GO:0007517 IEA muscle organ development
GO:0007605 IEA sensory perception of sound
GO:0007626 IEA locomotory behavior
GO:0007628 IEA adult walking behavior
GO:0008344 IEA adult locomotory behavior
GO:0009636 IEA response to toxic substance
GO:0016020 IEA membrane
GO:0016021 TAS integral component of membrane
GO:0019228 IBA neuronal action potential
GO:0030018 ISS Z disc
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0033268 ISS node of Ranvier
GO:0034220 IEA ion transmembrane transport
GO:0034706 IEA sodium channel complex
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA sodium ion transmembrane transport
GO:0042552 ISS myelination
GO:0043025 IEA neuronal cell body
GO:0043194 ISS axon initial segment
GO:0050905 IEA neuromuscular process
GO:0055085 IEA transmembrane transport
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005775 scn8aa sodium channel, voltage-gated, type VIII, alpha a protein_coding Danio_rerio
ENSDARG00000018032 scn8ab sodium channel, voltage-gated, type VIII, alpha b protein_coding Danio_rerio
ENSMUSG00000023033 Scn8a sodium channel, voltage-gated, type VIII, alpha protein_coding Mus_musculus

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