C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secreted acidic cysteine rich glycoprotein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018593 Sparc 10090 - 11:55394500-55420080 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018737 Sparc-001 55394500-55420080 protein_coding
  ENSMUST00000108858 Sparc-002 55394500-55419898 protein_coding
  ENSMUST00000123775 Sparc-006 55395386-55399574 processed_transcript
  ENSMUST00000125787 Sparc-004 55409204-55419900 processed_transcript
  ENSMUST00000130642 Sparc-005 55395520-55402165 processed_transcript
  ENSMUST00000141530 Sparc-003 55399252-55419898 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018737ENSMUST00000108858ENSMUST00000130642ENSMUST00000141530
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018737 188.755±108.31 600.293±52.54 522.189±56.26 23.892±7.87 199.307±60.99 66.005±11.71 N/A 31.281±2.49 19.465±5.35 185.022±28.14 31.809±11.23 165.772±67.83 257.921±62.83 27.732±4.13
ENSMUST00000108858 1075.515±780.70 666.536±208.81 680.218±196.01 34.089±7.82 464.497±120.68 136.978±12.82 98.480±54.36 93.700±45.70 39.419±10.80 635.202±33.23 36.132±8.73 372.586±119.01 445.365±185.15 81.862±46.26
ENSMUST00000130642 1051.618±734.88 522.423±85.55 N/A N/A 397.552±0.00 110.659±10.11 N/A N/A N/A N/A N/A 484.775±61.80 N/A N/A
ENSMUST00000141530 N/A 841.376±55.54 N/A 53.338±0.00 445.872±43.32 179.672±35.55 N/A N/A N/A N/A N/A 603.256±77.54 N/A 176.558±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025X CIL_00025X_0002 CGP 11:55250609-55420080
CIL_0007IC CIL_0007IC_0003 CGP 11:55394500-55461239

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0005509 IEA calcium ion binding
GO:0005518 IEA collagen binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005604 IEA basement membrane
GO:0005615 IEA extracellular space
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0007165 IEA signal transduction
GO:0007507 IEA heart development
GO:0009629 IEA response to gravity
GO:0009986 IEA cell surface
GO:0010288 IEA response to lead ion
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0016363 IEA nuclear matrix
GO:0016525 IEA negative regulation of angiogenesis
GO:0022604 IEA regulation of cell morphogenesis
GO:0030324 IEA lung development
GO:0031012 IDA extracellular matrix
GO:0031091 IEA platelet alpha granule
GO:0031092 IEA platelet alpha granule membrane
GO:0031988 IEA membrane-bounded vesicle
GO:0032496 IEA response to lipopolysaccharide
GO:0033591 IEA response to L-ascorbic acid
GO:0034097 IEA response to cytokine
GO:0042060 IEA wound healing
GO:0042127 IGI regulation of cell proliferation
GO:0043434 IEA response to peptide hormone
GO:0045471 IEA response to ethanol
GO:0046686 IEA response to cadmium ion
GO:0048839 IEA inner ear development
GO:0050840 IDA extracellular matrix binding
GO:0051384 IEA response to glucocorticoid
GO:0051591 IEA response to cAMP
GO:0051592 IEA response to calcium ion
GO:0060348 IMP bone development
GO:0071363 IDA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019353 sparc secreted acidic cysteine rich glycoprotein protein_coding Danio_rerio
ENSG00000113140 SPARC secreted protein, acidic, cysteine-rich (osteonectin) protein_coding Homo_sapiens

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