C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SLIT-ROBO Rho GTPase activating protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026425 Srgap2 10090 - 1:131285251-131527352 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000097588 Srgap2-001 131285251-131527347 protein_coding
  ENSMUST00000185445 Srgap2-009 131411800-131514232 protein_coding
  ENSMUST00000185596 Srgap2-005 131296641-131364064 protein_coding
  ENSMUST00000186543 Srgap2-004 131295218-131527347 protein_coding
  ENSMUST00000187042 Srgap2-012 131289358-131300453 protein_coding
  ENSMUST00000187273 Srgap2-010 131436675-131504366 protein_coding
  ENSMUST00000188437 Srgap2-011 131319535-131332263 retained_intron
  ENSMUST00000188604 Srgap2-013 131295756-131296380 processed_transcript
  ENSMUST00000188770 Srgap2-006 131295221-131344547 protein_coding
  ENSMUST00000189892 Srgap2-008 131295219-131311065 processed_transcript
  ENSMUST00000189893 Srgap2-002 131362026-131527352 retained_intron
  ENSMUST00000190336 Srgap2-007 131294988-131333070 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000097588ENSMUST00000186543ENSMUST00000187042ENSMUST00000188770
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000097588 2.919±0.03 1.922±0.45 1.094±0.00 3.056±1.05 3.035±1.38 1.427±0.67 1.638±0.49 1.823±0.53 1.104±0.92 5.088±1.36 0.927±0.22 2.904±1.01 3.147±3.37 1.378±0.50
ENSMUST00000186543 3.170±0.00 2.212±0.00 3.478±0.00 9.550±0.00 3.026±1.24 1.304±0.62 1.224±0.00 1.859±0.34 1.482±0.98 3.489±0.00 1.183±0.15 2.667±0.89 7.825±5.62 2.640±1.22
ENSMUST00000187042 N/A 4.019±0.73 N/A N/A N/A 2.377±0.37 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000188770 5.823±1.23 4.442±0.48 N/A N/A 4.039±0.54 1.164±0.28 2.509±0.68 2.153±0.19 1.519±0.50 7.518±0.65 1.189±0.19 3.850±1.16 3.709±2.12 1.334±0.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005VZ CIL_0005VZ_0002 CGP 1:131254343-131527352
CIL_00012Y CIL_00012Y_0003 CGP 1:131285251-131539872

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005634 IEA nucleus
GO:0005743 IDA mitochondrial inner membrane
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0007165 IEA signal transduction
GO:0014069 IDA postsynaptic density
GO:0021816 IMP extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO:0030054 IEA cell junction
GO:0030675 IDA Rac GTPase activator activity
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0042803 IDA protein homodimerization activity
GO:0044327 ISS dendritic spine head
GO:0045211 IDA postsynaptic membrane
GO:0045335 IDA phagocytic vesicle
GO:0046847 IDA filopodium assembly
GO:0048365 IDA Rac GTPase binding
GO:0048812 IMP neuron projection morphogenesis
GO:0051014 ISS actin filament severing
GO:0060996 IMP dendritic spine development
GO:2001223 ISS negative regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032161 srgap2a SLIT-ROBO Rho GTPase activating protein 2a protein_coding Danio_rerio
ENSG00000171943 SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C protein_coding Homo_sapiens
ENSG00000196369 SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B protein_coding Homo_sapiens

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