C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transcription factor AP-2 beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000027059 Tfap2b-001 ENSMUSG00000025927 10090 + 1:19208914-19238576 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastKidneyLiverMuscleOvaryTestisENSMUST00000027059
Transcript ID Adrenal Bladder Brain Breast Kidney Liver Muscle Ovary Testis
ENSMUST00000027059 0.404±0.21 0.007±0.00 9.080±7.44 0.758±0.28 2.364±0.43 0.009±0.01 0.015±0.01 0.016±0.01 0.054±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MC CIL_0007MC_0006 UCNEbase 1:18307438-19700223
CIL_000813 CIL_000813_0002 VISTA 1:18655282-19257504
CIL_00096L CIL_00096L_0002 VISTA 1:18806734-19407712
CIL_0005MY CIL_0005MY_0002 CGP 1:19103022-19238576
CIL_0005MX CIL_0005MX_0002 CGP 1:19208914-20618064

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983 IDA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001106 IDA RNA polymerase II transcription corepressor activity
GO:0001158 IEA enhancer sequence-specific DNA binding
GO:0001822 IMP kidney development
GO:0003091 IMP renal water homeostasis
GO:0003682 IEA chromatin binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0006006 ISS glucose metabolic process
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007423 IEP sensory organ development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0010226 IEA response to lithium ion
GO:0010842 IEA retina layer formation
GO:0010960 IMP magnesium ion homeostasis
GO:0030510 IMP regulation of BMP signaling pathway
GO:0035136 IMP forelimb morphogenesis
GO:0035137 IMP hindlimb morphogenesis
GO:0035810 IMP positive regulation of urine volume
GO:0035909 IMP aorta morphogenesis
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0042803 IEA protein homodimerization activity
GO:0043027 IMP cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0043565 ISS sequence-specific DNA binding
GO:0043588 IEP skin development
GO:0045444 IEP fat cell differentiation
GO:0045595 ISS regulation of cell differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0046983 ISS protein dimerization activity
GO:0048485 IGI sympathetic nervous system development
GO:0050796 ISS regulation of insulin secretion
GO:0055062 IMP phosphate ion homeostasis
GO:0055074 IMP calcium ion homeostasis
GO:0055075 IMP potassium ion homeostasis
GO:0055078 IMP sodium ion homeostasis
GO:0072017 IMP distal tubule development
GO:0072044 IMP collecting duct development
GO:0072210 IEP metanephric nephron development
GO:0097070 IMP ductus arteriosus closure
GO:0097275 IMP cellular ammonia homeostasis
GO:0097276 IMP cellular creatinine homeostasis
GO:0097277 IMP cellular urea homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000013003 tfap2b-201 protein_coding Danio_rerio 0.00000001 68
ENSDART00000024898 tfap2b-202 protein_coding Danio_rerio 0.00000001 68
ENSDART00000060539 tfap2b-203 protein_coding Danio_rerio 0.00000001 68
ENSDART00000132105 tfap2b-001 protein_coding Danio_rerio 0.00000001 68
ENST00000319516 TFAP2A-003 protein_coding Homo_sapiens 0 296
ENST00000344788 TFAP2B-002 protein_coding Homo_sapiens 0 987
ENST00000379604 TFAP2A-201 protein_coding Homo_sapiens 0 296
ENST00000379608 TFAP2A-005 protein_coding Homo_sapiens 0 296
ENST00000379613 TFAP2A-001 protein_coding Homo_sapiens 0 296
ENST00000393655 TFAP2B-001 protein_coding Homo_sapiens 0 2784
ENST00000482890 TFAP2A-007 protein_coding Homo_sapiens 0 296
ENST00000488193 TFAP2A-008 nonsense_mediated_decay Homo_sapiens 0 296
ENST00000489228 TFAP2B-003 processed_transcript Homo_sapiens 0 601
ENST00000489805 TFAP2A-011 nonsense_mediated_decay Homo_sapiens 0 296

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