C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: runt-related transcription factor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371438 RUNX2-003 ENSG00000124813 9606 + 6:45328369-45551079 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonOvaryENST00000371438
Transcript ID Colon Ovary
ENST00000371438 0.304±0.00 0.244±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028U CIL_00028U_0002 CGP 6:44387525-45377953
CIL_00028T CIL_00028T_0002 CGP 6:44809317-45664349
CIL_0007Z9 CIL_0007Z9_0001 VISTA 6:45132802-45734411
CIL_00082L CIL_00082L_0001 VISTA 6:45237622-45839555
CIL_00008A CIL_00008A_0003 CGP 6:45328157-46080395

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000790 ISS nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001501 IEA skeletal system development
GO:0001503 TAS ossification
GO:0001649 TAS osteoblast differentiation
GO:0001958 IEA endochondral ossification
GO:0002051 IEA osteoblast fate commitment
GO:0002062 IEA chondrocyte differentiation
GO:0002063 IEA chondrocyte development
GO:0002076 IEA osteoblast development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008284 IEA positive regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0019904 IEA protein domain specific binding
GO:0030217 IEA T cell differentiation
GO:0030278 IEA regulation of ossification
GO:0030509 ISS BMP signaling pathway
GO:0032332 IEA positive regulation of chondrocyte differentiation
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0040036 IEA regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042487 IEA regulation of odontogenesis of dentin-containing tooth
GO:0043425 IEA bHLH transcription factor binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045667 IEA regulation of osteoblast differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048469 IEA cell maturation
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0048863 IEA stem cell differentiation
GO:0070491 IEA repressing transcription factor binding
GO:0071773 ISS cellular response to BMP stimulus
GO:1901522 ISS positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000159943 Runx2-003 protein_coding Mus_musculus 0 2988
ENSMUST00000113571 Runx2-201 protein_coding Mus_musculus 0 2556
ENSMUST00000160673 Runx2-001 protein_coding Mus_musculus 0 2447
ENSMUST00000113572 Runx2-002 protein_coding Mus_musculus 0 2362
ENSMUST00000113568 Runx2-004 nonsense_mediated_decay Mus_musculus 0 1626
ENSMUST00000162629 Runx2-011 protein_coding Mus_musculus 0 1439
ENSMUST00000162373 Runx2-012 protein_coding Mus_musculus 0 1356
ENSMUST00000162878 Runx2-009 protein_coding Mus_musculus 0 1238
ENSMUST00000162816 Runx2-008 nonsense_mediated_decay Mus_musculus 0 813
ENSMUST00000162130 Runx2-010 protein_coding Mus_musculus 0 560
ENSMUST00000160672 Runx2-006 nonsense_mediated_decay Mus_musculus 0 342
ENSMUST00000160199 Runx2-014 protein_coding Mus_musculus 0 340
ENSMUST00000119564 Runx3-002 protein_coding Mus_musculus 0 327
ENSMUST00000056977 Runx3-001 protein_coding Mus_musculus 0 327
ENSMUST00000156478 Runx3-003 retained_intron Mus_musculus 0 243
ENSMUST00000161489 Runx2-005 retained_intron Mus_musculus 0 196

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