C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actinin, alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000072110 ACTN1 9606 - 14:68874143-68979440 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000193403 ACTN1-001 68874143-68979440 protein_coding
  ENST00000376839 ACTN1-007 68874783-68977566 protein_coding
  ENST00000394419 ACTN1-005 68874323-68979239 protein_coding
  ENST00000438964 ACTN1-002 68874686-68979262 protein_coding
  ENST00000538545 ACTN1-006 68874859-68979076 protein_coding
  ENST00000544964 ACTN1-019 68879046-68890142 protein_coding
  ENST00000553290 ACTN1-020 68879049-68884303 protein_coding
  ENST00000553370 ACTN1-015 68904702-68977654 protein_coding
  ENST00000553659 ACTN1-013 68925559-68978269 protein_coding
  ENST00000553779 ACTN1-016 68910020-68947548 protein_coding
  ENST00000553882 ACTN1-009 68874323-68879022 retained_intron
  ENST00000554158 ACTN1-017 68902543-68921359 processed_transcript
  ENST00000554508 ACTN1-018 68893703-68921038 processed_transcript
  ENST00000555075 ACTN1-022 68874786-68882567 protein_coding
  ENST00000555616 ACTN1-012 68892228-68978289 protein_coding
  ENST00000556083 ACTN1-008 68874318-68888263 retained_intron
  ENST00000556203 ACTN1-010 68973781-68979031 processed_transcript
  ENST00000556343 ACTN1-021 68883265-68884295 processed_transcript
  ENST00000556432 ACTN1-023 68879864-68881122 retained_intron
  ENST00000556433 ACTN1-011 68893665-68978735 protein_coding
  ENST00000556571 ACTN1-014 68910022-68978240 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000193403ENST00000376839ENST00000394419ENST00000438964ENST00000538545ENST00000553882
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000193403 7.681±0.00 49.015±0.00 4.412±0.00 8.185±0.27 24.584±2.44 46.638±33.77 5.959±3.68 8.886±2.64 36.321±0.00 18.241±12.72 0.938±0.44 33.523±24.85 29.665±9.99 13.578±9.38
ENST00000376839 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 16.146±0.00 2.969±0.00
ENST00000394419 9.511±0.00 32.861±0.00 N/A N/A 19.521±0.00 54.483±0.00 6.040±0.00 15.632±0.00 20.645±0.00 39.663±0.00 4.140±0.00 8.461±0.00 15.539±0.50 21.904±0.00
ENST00000438964 30.447±0.00 89.458±0.00 N/A 13.032±0.00 46.574±0.00 67.105±0.00 11.277±0.00 12.574±0.00 27.998±0.00 49.721±0.00 3.589±2.61 36.380±17.44 24.170±6.68 18.124±13.43
ENST00000538545 N/A N/A N/A 2.336±0.00 17.563±0.00 5.752±0.00 1.887±0.00 1.758±0.00 N/A 5.569±0.00 1.659±0.00 6.214±0.00 N/A N/A
ENST00000553882 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.080±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002CK CIL_0002CK_0001 CGP 14:68787660-68979440
CIL_0001JZ CIL_0001JZ_0002 CGP 14:68874143-69153150

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001725 IEA stress fiber
GO:0002576 TAS platelet degranulation
GO:0003725 IDA double-stranded RNA binding
GO:0005178 IDA integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005916 IEA fascia adherens
GO:0005925 IMP focal adhesion
GO:0007596 TAS blood coagulation
GO:0017166 IPI vinculin binding
GO:0019904 IEA protein domain specific binding
GO:0030018 IEA Z disc
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030864 IEA cortical actin cytoskeleton
GO:0031093 TAS platelet alpha granule lumen
GO:0031143 TAS pseudopodium
GO:0034329 TAS cell junction assembly
GO:0042981 NAS regulation of apoptotic process
GO:0042995 IDA cell projection
GO:0043197 IEA dendritic spine
GO:0044325 IPI ion channel binding
GO:0048041 IMP focal adhesion assembly
GO:0051015 IEA actin filament binding
GO:0051017 IEA actin filament bundle assembly
GO:0051271 IMP negative regulation of cellular component movement
GO:0051764 IEA actin crosslink formation
GO:0070062 IDA extracellular vesicular exosome
GO:0070830 IEA tight junction assembly
GO:1902396 IEA protein localization to tight junction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007219 actn1 actinin, alpha 1 protein_coding Danio_rerio
ENSMUSG00000015143 Actn1 actinin, alpha 1 protein_coding Mus_musculus

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