C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine hydroxymethyltransferase 2 (mitochondrial)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182199 SHMT2 9606 + 12:57229327-57234935 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000328923 SHMT2-001 57229327-57234931 protein_coding
  ENST00000414700 SHMT2-005 57230086-57234726 protein_coding
  ENST00000449049 SHMT2-008 57230360-57234699 protein_coding
  ENST00000553324 SHMT2-017 57229711-57231979 retained_intron
  ENST00000553474 SHMT2-009 57230328-57234551 protein_coding
  ENST00000553529 SHMT2-022 57230167-57231906 protein_coding
  ENST00000553837 SHMT2-011 57230384-57234726 nonsense_mediated_decay
  ENST00000553868 SHMT2-032 57231162-57232399 retained_intron
  ENST00000553949 SHMT2-037 57230701-57232261 processed_transcript
  ENST00000553950 SHMT2-018 57229715-57231769 retained_intron
  ENST00000554310 SHMT2-023 57230167-57232241 protein_coding
  ENST00000554467 SHMT2-002 57229711-57234726 retained_intron
  ENST00000554600 SHMT2-034 57229684-57232572 processed_transcript
  ENST00000554604 SHMT2-036 57230394-57232801 nonsense_mediated_decay
  ENST00000554656 SHMT2-026 57230275-57232534 processed_transcript
  ENST00000554975 SHMT2-028 57230360-57232568 protein_coding
  ENST00000555116 SHMT2-010 57230368-57234763 nonsense_mediated_decay
  ENST00000555213 SHMT2-031 57231448-57232487 retained_intron
  ENST00000555563 SHMT2-035 57229749-57233239 nonsense_mediated_decay
  ENST00000555634 SHMT2-019 57229723-57233811 protein_coding
  ENST00000555773 SHMT2-027 57230354-57231913 protein_coding
  ENST00000555774 SHMT2-012 57230360-57234935 nonsense_mediated_decay
  ENST00000556689 SHMT2-033 57229724-57232822 protein_coding
  ENST00000556737 SHMT2-038 57230703-57231906 protein_coding
  ENST00000556798 SHMT2-029 57233634-57234244 retained_intron
  ENST00000556825 SHMT2-004 57229573-57234935 nonsense_mediated_decay
  ENST00000557269 SHMT2-020 57229740-57232773 nonsense_mediated_decay
  ENST00000557302 SHMT2-024 57230171-57231185 retained_intron
  ENST00000557348 SHMT2-006 57230103-57234476 nonsense_mediated_decay
  ENST00000557427 SHMT2-025 57230280-57232238 protein_coding
  ENST00000557433 SHMT2-013 57229759-57234726 nonsense_mediated_decay
  ENST00000557487 SHMT2-015 57229711-57234726 protein_coding
  ENST00000557529 SHMT2-030 57232461-57234694 protein_coding
  ENST00000557703 SHMT2-021 57230115-57231890 protein_coding
  ENST00000557740 SHMT2-016 57229661-57231913 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000414700ENST00000449049ENST00000553474ENST00000553868ENST00000553950ENST00000555116ENST00000555634ENST00000556689ENST00000556825ENST00000557433ENST00000557487ENST00000557529ENST00000557740
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000414700 N/A N/A N/A N/A N/A N/A N/A 6.696±0.00 16.247±0.00 N/A N/A 6.736±0.00 22.096±4.17 N/A
ENST00000449049 N/A N/A N/A N/A 1.369±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000553474 N/A N/A N/A N/A N/A 10.404±0.00 N/A N/A N/A N/A N/A 17.091±14.23 19.264±0.00 2.210±0.00
ENST00000553868 N/A N/A N/A N/A N/A 1.305±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000553950 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.277±0.00 N/A N/A N/A
ENST00000555116 N/A N/A N/A 0.703±0.00 N/A N/A N/A 8.048±0.00 22.331±0.00 N/A 7.235±0.00 N/A N/A N/A
ENST00000555634 18.166±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000556689 N/A N/A N/A N/A N/A N/A N/A N/A 1.293±0.00 N/A N/A N/A N/A N/A
ENST00000556825 N/A N/A N/A N/A N/A N/A 0.519±0.00 N/A N/A N/A N/A 16.444±0.00 N/A N/A
ENST00000557433 16.599±0.00 17.406±0.00 N/A 2.480±0.00 14.573±0.00 13.023±0.00 5.423±0.00 21.449±0.00 36.159±0.00 9.314±0.00 12.049±0.00 23.897±14.48 N/A 6.596±4.86
ENST00000557487 N/A N/A 1.805±0.00 1.448±0.00 1.095±0.00 1.329±0.00 N/A 6.645±0.00 30.209±0.00 0.640±0.00 11.063±0.00 16.483±11.03 16.628±0.00 N/A
ENST00000557529 N/A N/A N/A 0.998±0.00 N/A N/A N/A 6.260±0.00 0.841±0.00 N/A 1.510±0.00 N/A N/A N/A
ENST00000557740 N/A N/A N/A N/A N/A N/A 0.902±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KV CIL_0002KV_0002 CGP 12:57216795-57234935
CIL_0002KW CIL_0002KW_0002 CGP 12:57229327-57240715

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003682 IDA chromatin binding
GO:0004372 IEA:IDA glycine hydroxymethyltransferase activity
GO:0005739 IDA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0005758 IEA mitochondrial intermembrane space
GO:0005759 IDA mitochondrial matrix
GO:0006544 IEA glycine metabolic process
GO:0006545 IEA glycine biosynthetic process
GO:0006563 IEA L-serine metabolic process
GO:0006564 IEA L-serine biosynthetic process
GO:0006730 IDA one-carbon metabolic process
GO:0008284 IEA positive regulation of cell proliferation
GO:0008732 IEA L-allo-threonine aldolase activity
GO:0015630 IDA microtubule cytoskeleton
GO:0016597 IEA amino acid binding
GO:0019264 IEA glycine biosynthetic process from serine
GO:0030170 IEA pyridoxal phosphate binding
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042645 IDA mitochondrial nucleoid
GO:0042802 IEA identical protein binding
GO:0051289 IEA protein homotetramerization
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068724 shmt2 serine hydroxymethyltransferase 2 (mitochondrial) protein_coding Danio_rerio
ENSMUSG00000025403 Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) protein_coding Mus_musculus

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