C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000215301 DDX3X 9606 + X:41333348-41364472 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000399959 DDX3X-001 41333398-41350274 protein_coding
  ENST00000441189 DDX3X-005 41334162-41348259 protein_coding
  ENST00000457138 DDX3X-201 41333398-41350269 protein_coding
  ENST00000478993 DDX3X-002 41333398-41364472 nonsense_mediated_decay
  ENST00000480592 DDX3X-003 41334174-41338509 processed_transcript
  ENST00000542215 DDX3X-004 41334591-41346551 processed_transcript
  ENST00000610559 DDX3X-010 41333348-41339083 processed_transcript
  ENST00000611546 DDX3X-008 41334670-41342520 processed_transcript
  ENST00000611968 DDX3X-012 41346566-41348138 protein_coding
  ENST00000615313 DDX3X-007 41334612-41342542 processed_transcript
  ENST00000615742 DDX3X-011 41334162-41342506 nonsense_mediated_decay
  ENST00000616050 DDX3X-013 41346361-41358000 processed_transcript
  ENST00000622198 DDX3X-009 41334670-41342518 processed_transcript
  ENST00000622373 DDX3X-006 41334610-41336738 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000399959ENST00000478993ENST00000542215
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000399959 N/A N/A N/A N/A N/A N/A N/A 4.177±0.00 33.464±12.00 31.434±0.00 18.865±2.51
ENST00000478993 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.185±0.00
ENST00000542215 30.270±0.00 13.634±0.00 28.309±0.00 27.896±0.00 12.557±0.00 13.790±0.00 32.540±0.00 21.482±0.00 42.695±0.00 20.341±0.00 68.049±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QB CIL_0005QB_0001 CGP X:41085635-41364472
CIL_0007LW CIL_0007LW_0001 UCNEbase X:41232520-41520330
CIL_0001X4 CIL_0001X4_0002 CGP X:41333348-41475710

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003677 IDA DNA binding
GO:0003723 IDA RNA binding
GO:0004003 IDA ATP-dependent DNA helicase activity
GO:0004004 IDA ATP-dependent RNA helicase activity
GO:0004386 IEA helicase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005852 IDA eukaryotic translation initiation factor 3 complex
GO:0006200 IEA ATP catabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0007059 IMP chromosome segregation
GO:0008134 IDA transcription factor binding
GO:0008143 IDA poly(A) binding
GO:0008152 IEA metabolic process
GO:0008190 IDA eukaryotic initiation factor 4E binding
GO:0008625 IMP extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615 IDA response to virus
GO:0010494 IDA cytoplasmic stress granule
GO:0010501 IDA RNA secondary structure unwinding
GO:0016032 IEA viral process
GO:0016887 IDA ATPase activity
GO:0017148 IMP negative regulation of translation
GO:0022627 IDA cytosolic small ribosomal subunit
GO:0030307 IMP positive regulation of cell growth
GO:0030308 IDA negative regulation of cell growth
GO:0031333 IDA negative regulation of protein complex assembly
GO:0031369 IDA translation initiation factor binding
GO:0032508 IDA DNA duplex unwinding
GO:0032728 TAS positive regulation of interferon-beta production
GO:0034063 IDA stress granule assembly
GO:0035556 IDA intracellular signal transduction
GO:0035613 IDA RNA stem-loop binding
GO:0042256 IMP mature ribosome assembly
GO:0043024 IDA ribosomal small subunit binding
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IMP negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044822 IDA poly(A) RNA binding
GO:0045087 IMP innate immune response
GO:0045727 IDA positive regulation of translation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045948 IMP positive regulation of translational initiation
GO:0048027 IDA mRNA 5'-UTR binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071243 IDA cellular response to arsenic-containing substance
GO:0071470 IDA cellular response to osmotic stress
GO:0071651 TAS positive regulation of chemokine (C-C motif) ligand 5 production
GO:0097193 IMP intrinsic apoptotic signaling pathway
GO:1900087 IMP positive regulation of G1/S transition of mitotic cell cycle
GO:2001243 IMP negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005774 pl10 pl10 protein_coding Danio_rerio
ENSDARG00000020573 ddx3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 protein_coding Danio_rerio
ENSMUSG00000000787 Ddx3x DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked protein_coding Mus_musculus
ENSMUSG00000039224 D1Pas1 DNA segment, Chr 1, Pasteur Institute 1 protein_coding Mus_musculus

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