C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: RAB guanine nucleotide exchange factor (GEF) 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000026390 Rabgef1-002 ENSMUSG00000025340 10090 + 5:130187161-130214337 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonLiverOvaryENSMUST00000026390
Transcript ID Adrenal Breast Colon Liver Ovary
ENSMUST00000026390 4.992±0.42 4.294±1.94 5.219±0.27 0.771±0.00 4.872±1.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005UP CIL_0005UP_0002 CGP 5:130144861-130214342
CIL_000256 CIL_000256_0002 CGP 5:130171798-130243765

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0002686 IMP negative regulation of leukocyte migration
GO:0003677 IEA DNA binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005769 IEA early endosome
GO:0006612 IEA protein targeting to membrane
GO:0006897 IEA endocytosis
GO:0008270 IEA zinc ion binding
GO:0015031 IEA protein transport
GO:0016567 IDA protein ubiquitination
GO:0017112 IEA Rab guanyl-nucleotide exchange factor activity
GO:0017137 IEA Rab GTPase binding
GO:0031982 IDA vesicle
GO:0032851 IEA positive regulation of Rab GTPase activity
GO:0033004 IMP negative regulation of mast cell activation
GO:0043305 IMP negative regulation of mast cell degranulation
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048261 IMP negative regulation of receptor-mediated endocytosis
GO:0050728 IMP negative regulation of inflammatory response
GO:0060368 IMP regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 IMP negative regulation of interleukin-6 secretion
GO:1900235 IMP negative regulation of Kit signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000284957 RABGEF1-001 protein_coding Homo_sapiens 0 1895
ENST00000380828 RABGEF1-201 protein_coding Homo_sapiens 0 1895
ENST00000411606 GS1-124K5.2-003 transcribed_unprocessed_pseudogene Homo_sapiens 0 231
ENST00000428370 GS1-124K5.12-001 unprocessed_pseudogene Homo_sapiens 0 296
ENST00000437078 RABGEF1-202 protein_coding Homo_sapiens 0 1223
ENST00000439720 RABGEF1-003 protein_coding Homo_sapiens 0 1895
ENST00000442563 RABGEF1-005 protein_coding Homo_sapiens 0 230
ENST00000449786 AC005077.7-001 unprocessed_pseudogene Homo_sapiens 0 316
ENST00000450873 RABGEF1-002 protein_coding Homo_sapiens 0 1888
ENST00000461017 RABGEF1-006 processed_transcript Homo_sapiens 0 606
ENST00000484547 RABGEF1-004 processed_transcript Homo_sapiens 0 1133
ENST00000503687 KCTD7-004 nonsense_mediated_decay Homo_sapiens 0 1133
ENST00000510829 RABGEF1-203 protein_coding Homo_sapiens 0 1129
ENST00000607882 RABGEF1-007 nonsense_mediated_decay Homo_sapiens 0 1149

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