C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: high mobility group box 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000066551 Hmgb1 10090 - 5:149046702-149053513 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000085546 Hmgb1-001 149046702-149053040 protein_coding
  ENSMUST00000093196 Hmgb1-002 149048645-149051616 protein_coding
  ENSMUST00000110505 Hmgb1-003 149048228-149051300 protein_coding
  ENSMUST00000123645 Hmgb1-005 149050373-149052981 retained_intron
  ENSMUST00000125605 Hmgb1-008 149050315-149053513 protein_coding
  ENSMUST00000133667 Hmgb1-004 149050068-149053016 retained_intron
  ENSMUST00000138553 Hmgb1-007 149049824-149052377 protein_coding
  ENSMUST00000139443 Hmgb1-006 149049401-149053011 retained_intron
  ENSMUST00000155086 Hmgb1-009 149049153-149050447 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000085546ENSMUST00000093196ENSMUST00000110505ENSMUST00000133667ENSMUST00000138553
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000085546 14.521±5.24 4.362±1.41 22.657±10.21 28.403±19.52 13.205±2.80 11.696±2.24 11.779±2.25 22.391±5.26 36.485±24.90 26.854±3.08 11.162±4.84 15.846±6.56 22.414±15.82 5.063±0.94
ENSMUST00000093196 N/A N/A 31.658±6.67 38.022±0.00 N/A N/A N/A N/A 54.916±2.80 N/A N/A 78.038±38.35 55.989±30.73 38.198±0.00
ENSMUST00000110505 4.592±0.46 N/A 13.370±2.51 40.525±0.51 4.237±1.35 N/A 3.588±0.05 N/A 42.354±9.94 N/A 22.129±0.00 15.413±14.45 13.762±1.78 3.990±0.29
ENSMUST00000133667 12.337±0.06 5.830±1.31 50.456±0.00 45.608±0.00 N/A 19.282±5.55 9.123±0.00 17.101±2.39 95.557±0.00 21.691±1.84 N/A 13.069±3.23 70.477±3.15 9.020±0.73
ENSMUST00000138553 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 139.411±70.11 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UA CIL_0007UA_0002 VISTA 5:149020224-149622595
CIL_0004CF CIL_0004CF_0002 CGP 5:149046702-149215434

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000793 IEA condensed chromosome
GO:0001786 TAS phosphatidylserine binding
GO:0002437 IEA inflammatory response to antigenic stimulus
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006288 IEA base-excision repair, DNA ligation
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006954 TAS inflammatory response
GO:0008134 IEA transcription factor binding
GO:0008201 IEA heparin binding
GO:0009986 IEA cell surface
GO:0017053 IEA transcriptional repressor complex
GO:0017055 IEA negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0033151 IEA V(D)J recombination
GO:0043065 IEA positive regulation of apoptotic process
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 IEA positive regulation of DNA binding
GO:0044822 IEA poly(A) RNA binding
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0070491 IEA repressing transcription factor binding
GO:2000426 IDA negative regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030479 hmgb1b high-mobility group box 1b protein_coding Danio_rerio
ENSDARG00000079772 hmgb1a high-mobility group box 1a protein_coding Danio_rerio
ENSG00000189403 HMGB1 high mobility group box 1 protein_coding Homo_sapiens

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