C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type I, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000064329 Scn1a 10090 - 2:66270781-66440840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000077489 Scn1a-004 66270784-66351195 protein_coding
  ENSMUST00000094951 Scn1a-005 66272884-66351177 protein_coding
  ENSMUST00000112366 Scn1a-001 66270781-66410064 protein_coding
  ENSMUST00000112371 Scn1a-201 66270782-66440837 protein_coding
  ENSMUST00000129508 Scn1a-002 66348364-66440814 processed_transcript
  ENSMUST00000138910 Scn1a-006 66335443-66440840 protein_coding
  ENSMUST00000156865 Scn1a-003 66272892-66318139 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000077489ENSMUST00000094951ENSMUST00000112366ENSMUST00000112371ENSMUST00000138910ENSMUST00000156865
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000077489 0.033±0.03 N/A 0.070±0.00 2.704±0.00 0.014±0.00 N/A 0.008±0.00 0.012±0.01 0.004±0.00 0.026±0.00 0.010±0.01 0.027±0.01 0.006±0.00 0.116±0.04
ENSMUST00000094951 0.016±0.00 0.042±0.03 N/A N/A 0.014±0.00 N/A 0.022±0.01 N/A 0.007±0.01 N/A 0.014±0.00 0.079±0.05 N/A 0.055±0.01
ENSMUST00000112366 N/A N/A N/A 1.208±0.88 N/A N/A 0.028±0.00 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000112371 N/A N/A N/A 1.577±1.47 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000138910 N/A N/A N/A N/A N/A N/A 0.132±0.00 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000156865 0.016±0.00 N/A N/A 8.606±0.00 0.040±0.02 0.041±0.00 N/A 0.024±0.02 N/A 0.025±0.00 N/A 0.016±0.01 N/A 0.120±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087V CIL_00087V_0002 VISTA 2:65692128-66294633
CIL_0006CL CIL_0006CL_0002 CGP 2:66184327-66440840
CIL_0006CK CIL_0006CK_0002 CGP 2:66270781-66634962

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001508 IMP action potential
GO:0001518 IEA voltage-gated sodium channel complex
GO:0005248 IMP voltage-gated sodium channel activity
GO:0006814 IMP sodium ion transport
GO:0007628 IMP adult walking behavior
GO:0014704 IDA intercalated disc
GO:0016020 IDA membrane
GO:0019227 IMP neuronal action potential propagation
GO:0019228 IMP neuronal action potential
GO:0030018 IDA Z disc
GO:0030315 IDA T-tubule
GO:0030424 IDA axon
GO:0033268 IDA node of Ranvier
GO:0034706 IPI sodium channel complex
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA sodium ion transmembrane transport
GO:0042391 IMP regulation of membrane potential
GO:0043025 IDA neuronal cell body
GO:0043194 IDA axon initial segment
GO:0050884 IMP neuromuscular process controlling posture
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010783 scn1a sodium channel, voltage-gated, type I, alpha protein_coding Danio_rerio
ENSDARG00000062744 scn1lab sodium channel, voltage-gated, type I like, alpha b protein_coding Danio_rerio
ENSG00000144285 SCN1A sodium channel, voltage-gated, type I, alpha subunit protein_coding Homo_sapiens

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