C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000320354 FOXC2-001 ENSG00000176692 9606 + 16:86567251-86569728 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000320354
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000320354 0.676±0.00 3.087±0.00 0.207±0.00 0.252±0.14 0.638±0.00 0.750±0.00 0.709±0.59 0.016±0.00 2.237±2.14 0.638±0.00 0.555±0.25 0.276±0.13 3.776±2.92

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008L5 CIL_0008L5_0001 VISTA 16:86096481-86697120
CIL_0008XN CIL_0008XN_0001 VISTA 16:86335014-86936242
CIL_00023B CIL_00023B_0001 CGP 16:86530176-86569728
CIL_00099Z CIL_00099Z_0001 VISTA 16:86565106-87168268
CIL_0002T4 CIL_0002T4_0001 CGP 16:86567251-86582160

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001501 IEA skeletal system development
GO:0001503 IEA ossification
GO:0001568 IEA blood vessel development
GO:0001569 IEA patterning of blood vessels
GO:0001656 IEA metanephros development
GO:0001657 IEA ureteric bud development
GO:0001756 IEA somitogenesis
GO:0001822 IEA kidney development
GO:0001945 IEA lymph vessel development
GO:0001946 IMP lymphangiogenesis
GO:0001974 IEA blood vessel remodeling
GO:0003007 IEA heart morphogenesis
GO:0003677 IEA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005634 IDA nucleus
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007219 IEA Notch signaling pathway
GO:0007498 NAS mesoderm development
GO:0007507 IMP heart development
GO:0008283 IEA cell proliferation
GO:0008286 IDA insulin receptor signaling pathway
GO:0009725 IDA response to hormone
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0014032 IEA neural crest cell development
GO:0030199 IEA collagen fibril organization
GO:0031490 IDA chromatin DNA binding
GO:0033630 ISS positive regulation of cell adhesion mediated by integrin
GO:0035050 IEA embryonic heart tube development
GO:0035470 ISS positive regulation of vascular wound healing
GO:0043010 IEA camera-type eye development
GO:0043565 IDA:IEA sequence-specific DNA binding
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046620 IEA regulation of organ growth
GO:0048010 IEA vascular endothelial growth factor receptor signaling pathway
GO:0048341 IEA paraxial mesoderm formation
GO:0048343 IEA paraxial mesodermal cell fate commitment
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048703 IEA embryonic viscerocranium morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0048844 IEA artery morphogenesis
GO:0050880 IEA regulation of blood vessel size
GO:0055010 IEA ventricular cardiac muscle tissue morphogenesis
GO:0060038 IEA cardiac muscle cell proliferation
GO:0072011 IEA glomerular endothelium development
GO:0072112 IEA glomerular visceral epithelial cell differentiation
GO:0072144 IEA glomerular mesangial cell development
GO:0090050 ISS positive regulation of cell migration involved in sprouting angiogenesis
GO:1902257 IEA negative regulation of apoptotic process involved in outflow tract morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000054691 Foxc2-001 protein_coding Mus_musculus 0 1781
ENSMUST00000062292 Foxc1-001 protein_coding Mus_musculus 0 507
ENSDART00000077753 foxc1b-001 protein_coding Danio_rerio 0 303
ENSDART00000122732 foxc1a-001 protein_coding Danio_rerio 0 298
ENSMUST00000087285 Foxd3-001 protein_coding Mus_musculus 0 272
ENSMUST00000181609 Foxl1-001 protein_coding Mus_musculus 0 254
ENSMUST00000095097 Foxe1-001 protein_coding Mus_musculus 0 211
ENSMUST00000105098 Foxd1-001 protein_coding Mus_musculus 0 209
ENSMUST00000072915 Foxb2-201 protein_coding Mus_musculus 0 204
ENSMUST00000058600 Foxd4-201 protein_coding Mus_musculus 6e-39 167
ENSMUST00000042054 Foxf2-001 protein_coding Mus_musculus 7e-23 113

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