C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000076928 ARHGEF1 9606 + 19:41883161-41930150 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337665 ARHGEF1-006 41884448-41907454 protein_coding
  ENST00000347545 ARHGEF1-001 41883225-41907454 protein_coding
  ENST00000354532 ARHGEF1-005 41883161-41907443 protein_coding
  ENST00000378152 ARHGEF1-007 41884370-41907454 protein_coding
  ENST00000593609 ARHGEF1-023 41906576-41907452 retained_intron
  ENST00000594044 ARHGEF1-018 41898424-41903407 retained_intron
  ENST00000594258 ARHGEF1-017 41897811-41902897 protein_coding
  ENST00000594417 ARHGEF1-024 41923094-41930127 protein_coding
  ENST00000594513 ARHGEF1-026 41928590-41929846 processed_transcript
  ENST00000594521 ARHGEF1-015 41894292-41902030 protein_coding
  ENST00000595723 ARHGEF1-022 41902798-41906561 protein_coding
  ENST00000595770 ARHGEF1-025 41928820-41930150 retained_intron
  ENST00000595897 ARHGEF1-011 41897675-41907454 retained_intron
  ENST00000596957 ARHGEF1-013 41883224-41892528 processed_transcript
  ENST00000598444 ARHGEF1-021 41905800-41906335 retained_intron
  ENST00000598587 ARHGEF1-020 41905513-41905982 retained_intron
  ENST00000598812 ARHGEF1-014 41892634-41895373 nonsense_mediated_decay
  ENST00000599589 ARHGEF1-009 41895379-41930150 protein_coding
  ENST00000599846 ARHGEF1-010 41883184-41907448 protein_coding
  ENST00000600274 ARHGEF1-002 41883183-41907454 retained_intron
  ENST00000600387 ARHGEF1-012 41883173-41890776 retained_intron
  ENST00000600517 ARHGEF1-019 41904216-41906043 nonsense_mediated_decay
  ENST00000617585 ARHGEF1-016 41894487-41896878 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337665ENST00000347545ENST00000354532ENST00000378152ENST00000594044ENST00000594258ENST00000595897ENST00000598812ENST00000599846ENST00000600274ENST00000600387
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337665 N/A N/A N/A N/A N/A N/A N/A 0.818±0.00 1.837±0.00 N/A N/A 8.133±6.22 15.351±5.41 3.860±0.00
ENST00000347545 N/A N/A N/A N/A N/A 1.096±0.00 N/A N/A N/A 2.053±0.00 N/A 10.575±2.26 10.801±0.00 3.008±0.00
ENST00000354532 29.432±0.00 54.017±0.00 0.455±0.00 0.187±0.00 7.252±4.85 7.031±0.00 1.412±1.07 17.781±0.00 3.824±0.00 17.391±0.00 1.938±0.00 14.683±0.00 15.423±0.00 7.024±0.00
ENST00000378152 N/A N/A N/A 0.133±0.00 0.768±0.00 3.440±0.00 0.171±0.00 N/A N/A N/A N/A 5.274±0.00 N/A N/A
ENST00000594044 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 19.434±15.86 N/A N/A
ENST00000594258 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.395±0.00 N/A N/A N/A
ENST00000595897 N/A 62.432±0.00 0.611±0.00 3.673±0.00 N/A N/A 1.403±0.00 N/A 2.230±0.00 7.157±5.51 N/A 4.808±0.00 N/A 5.452±0.00
ENST00000598812 N/A N/A N/A N/A 3.635±0.00 N/A N/A N/A N/A N/A 0.384±0.00 N/A N/A N/A
ENST00000599846 N/A N/A N/A 3.016±0.00 N/A 3.464±0.00 1.184±0.00 N/A N/A 10.010±0.00 1.456±0.00 N/A N/A N/A
ENST00000600274 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.559±0.00 N/A N/A N/A
ENST00000600387 N/A N/A 0.350±0.00 0.222±0.00 N/A 0.876±0.00 0.141±0.00 0.441±0.00 1.213±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003UK CIL_0003UK_0002 CGP 19:41877120-41930150
CIL_0003VE CIL_0003VE_0001 CGP 19:41883161-41959390

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI protein binding
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0007266 TAS Rho protein signal transduction
GO:0008283 TAS cell proliferation
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0044822 IDA poly(A) RNA binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050770 TAS regulation of axonogenesis
GO:0050771 TAS negative regulation of axonogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055837 arhgef1b Rho guanine nucleotide exchange factor (GEF) 1b protein_coding Danio_rerio
ENSMUSG00000040940 Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 protein_coding Mus_musculus

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