C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired box 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000007372 PAX6 9606 - 11:31784792-31817961 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000241001 PAX6-002 31789913-31811237 protein_coding
  ENST00000379107 PAX6-011 31789182-31810305 protein_coding
  ENST00000379109 PAX6-004 31789936-31810667 protein_coding
  ENST00000379111 PAX6-005 31789922-31811045 protein_coding
  ENST00000379115 PAX6-001 31789917-31811331 protein_coding
  ENST00000379123 PAX6-003 31789922-31811677 protein_coding
  ENST00000379129 PAX6-009 31788910-31817961 protein_coding
  ENST00000379132 PAX6-008 31788910-31817961 protein_coding
  ENST00000419022 PAX6-201 31784792-31817961 protein_coding
  ENST00000423822 PAX6-012 31801869-31817874 protein_coding
  ENST00000438681 PAX6-013 31802729-31811137 protein_coding
  ENST00000455099 PAX6-016 31794780-31806921 protein_coding
  ENST00000464174 PAX6-010 31789830-31817937 retained_intron
  ENST00000470027 PAX6-006 31789936-31804046 retained_intron
  ENST00000471303 PAX6-014 31794098-31804044 processed_transcript
  ENST00000474783 PAX6-017 31789918-31791309 retained_intron
  ENST00000481563 PAX6-015 31800707-31804025 processed_transcript
  ENST00000494377 PAX6-007 31789936-31803333 retained_intron
  ENST00000524853 PAX6-021 31801745-31812177 protein_coding
  ENST00000525535 PAX6-020 31806406-31812926 protein_coding
  ENST00000527769 PAX6-022 31806344-31811118 retained_intron
  ENST00000530373 PAX6-028 31793483-31800646 processed_transcript
  ENST00000530714 PAX6-025 31801617-31803673 processed_transcript
  ENST00000531910 PAX6-027 31793674-31801335 processed_transcript
  ENST00000532175 PAX6-023 31806344-31817948 retained_intron
  ENST00000532916 PAX6-030 31793173-31794126 retained_intron
  ENST00000533156 PAX6-029 31801728-31806013 processed_transcript
  ENST00000533333 PAX6-019 31789936-31811308 retained_intron
  ENST00000534353 PAX6-024 31801578-31804619 processed_transcript
  ENST00000534390 PAX6-026 31800763-31802971 retained_intron
  ENST00000606377 PAX6-202 31784792-31812183 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonHeartKidneyMuscleOvaryTestisENST00000379107ENST00000379109ENST00000379123ENST00000379129ENST00000379132ENST00000419022ENST00000464174ENST00000470027ENST00000494377ENST00000530714ENST00000606377
Transcript ID Brain Colon Heart Kidney Muscle Ovary Testis
ENST00000379107 3.777±0.00 N/A N/A N/A N/A N/A 0.556±0.20
ENST00000379109 N/A N/A N/A N/A N/A N/A 0.914±0.00
ENST00000379123 0.664±0.00 N/A N/A N/A N/A N/A N/A
ENST00000379129 0.712±0.00 N/A N/A N/A N/A N/A N/A
ENST00000379132 2.784±0.00 N/A N/A N/A N/A N/A 0.368±0.00
ENST00000419022 0.465±0.00 N/A N/A 0.018±0.00 N/A 0.033±0.00 N/A
ENST00000464174 2.401±0.00 N/A N/A N/A N/A N/A N/A
ENST00000470027 N/A 0.079±0.00 N/A N/A N/A N/A N/A
ENST00000494377 N/A N/A 0.021±0.00 N/A N/A N/A N/A
ENST00000530714 N/A N/A N/A 1.242±0.00 N/A N/A N/A
ENST00000606377 N/A N/A 0.020±0.00 0.018±0.00 0.024±0.00 N/A 0.156±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KI CIL_0008KI_0001 VISTA 11:31301275-31902571
CIL_0007UQ CIL_0007UQ_0001 VISTA 11:31363809-31965336
CIL_0008UP CIL_0008UP_0001 VISTA 11:31463875-32065678
CIL_0007XG CIL_0007XG_0001 VISTA 11:31494904-32096873
CIL_000914 CIL_000914_0001 VISTA 11:31574048-32177516
CIL_0007JA CIL_0007JA_0002 UCNEbase 11:31639896-31819124
CIL_0007PY CIL_0007PY_0001 VISTA 11:31667627-32268476
CIL_00096J CIL_00096J_0001 VISTA 11:31730852-32331950

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000132 IEA establishment of mitotic spindle orientation
GO:0000790 IDA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001227 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001568 IMP blood vessel development
GO:0001654 TAS eye development
GO:0001709 IEA cell fate determination
GO:0001755 IEA neural crest cell migration
GO:0001764 IEA neuron migration
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002064 IEA epithelial cell development
GO:0002088 IEA lens development in camera-type eye
GO:0003309 IEA type B pancreatic cell differentiation
GO:0003310 IEA pancreatic A cell differentiation
GO:0003322 IMP pancreatic A cell development
GO:0003677 IEA:TAS DNA binding
GO:0003680 IEA AT DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IEA:IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IMP transcription from RNA polymerase II promoter
GO:0007224 IEA smoothened signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007409 IEA axonogenesis
GO:0007411 IEA axon guidance
GO:0007417 TAS central nervous system development
GO:0007420 IEA brain development
GO:0007435 IEA salivary gland morphogenesis
GO:0007601 TAS visual perception
GO:0008134 ISS transcription factor binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009611 IEP response to wounding
GO:0009786 IEA regulation of asymmetric cell division
GO:0009887 TAS organ morphogenesis
GO:0009950 IEA dorsal/ventral axis specification
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0010468 IEA regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010975 IEA regulation of neuron projection development
GO:0016567 ISS protein ubiquitination
GO:0019901 ISS protein kinase binding
GO:0021510 IEA spinal cord development
GO:0021543 IEA pallium development
GO:0021549 IEA cerebellum development
GO:0021593 IEA rhombomere morphogenesis
GO:0021772 IEA olfactory bulb development
GO:0021778 IEA oligodendrocyte cell fate specification
GO:0021796 IEA cerebral cortex regionalization
GO:0021797 IEA forebrain anterior/posterior pattern specification
GO:0021798 IEA forebrain dorsal/ventral pattern formation
GO:0021902 IEA commitment of neuronal cell to specific neuron type in forebrain
GO:0021905 IEA forebrain-midbrain boundary formation
GO:0021912 IEA regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913 IEA regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021918 IEA regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
GO:0021978 IEA telencephalon regionalization
GO:0021983 IEA pituitary gland development
GO:0022027 IEA interkinetic nuclear migration
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030154 IEA cell differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030334 IEA regulation of cell migration
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0030900 IEA forebrain development
GO:0030902 IEA hindbrain development
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032808 IEA lacrimal gland development
GO:0032869 IEA cellular response to insulin stimulus
GO:0033365 IEA protein localization to organelle
GO:0035035 ISS histone acetyltransferase binding
GO:0035690 IEA cellular response to drug
GO:0042462 IEA eye photoreceptor cell development
GO:0042593 IMP glucose homeostasis
GO:0042660 IEA positive regulation of cell fate specification
GO:0043010 IEA camera-type eye development
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045165 IEA cell fate commitment
GO:0045471 IEA response to ethanol
GO:0045664 IEA regulation of neuron differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048505 IEA regulation of timing of cell differentiation
GO:0048596 IEA embryonic camera-type eye morphogenesis
GO:0048663 NAS neuron fate commitment
GO:0048708 IEA astrocyte differentiation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050767 IEA regulation of neurogenesis
GO:0050768 ISS negative regulation of neurogenesis
GO:0060041 IEA retina development in camera-type eye
GO:0061072 IMP iris morphogenesis
GO:0061303 IMP cornea development in camera-type eye
GO:0061351 IEA neural precursor cell proliferation
GO:0070094 IEA positive regulation of glucagon secretion
GO:0070410 IEA co-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0071333 IEA cellular response to glucose stimulus
GO:0071380 IEA cellular response to prostaglandin E stimulus
GO:0071837 IEA HMG box domain binding
GO:1901142 IEA insulin metabolic process
GO:2000178 IEA negative regulation of neural precursor cell proliferation
GO:2001224 IEA positive regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045045 pax6a paired box gene 6a protein_coding Danio_rerio
ENSDARG00000045936 pax6b paired box gene 6b protein_coding Danio_rerio
ENSMUSG00000027168 Pax6 paired box 6 protein_coding Mus_musculus

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