C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sodium channel, voltage-gated, type V, alpha subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000333535 SCN5A-014 ENSG00000183873 9606 - 3:38548066-38649628 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonHeartENST00000333535
Transcript ID Brain Colon Heart
ENST00000333535 0.115±0.00 0.026±0.00 13.010±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BE CIL_0008BE_0001 VISTA 3:38261144-38866061
CIL_0005VU CIL_0005VU_0001 CGP 3:38496127-38649673
CIL_0004RF CIL_0004RF_0001 CGP 3:38548057-38794010

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001518 IC:IEA voltage-gated sodium channel complex
GO:0002027 IMP regulation of heart rate
GO:0003231 ISS cardiac ventricle development
GO:0003360 ISS brainstem development
GO:0005216 IEA ion channel activity
GO:0005248 IDA:IEA voltage-gated sodium channel activity
GO:0005515 IPI protein binding
GO:0005516 IPI calmodulin binding
GO:0005783 IDA endoplasmic reticulum
GO:0005886 IDA plasma membrane
GO:0005901 IDA caveola
GO:0006811 IEA ion transport
GO:0006814 IDA:IEA sodium ion transport
GO:0009986 IDA cell surface
GO:0010765 IDA positive regulation of sodium ion transport
GO:0014704 ISS intercalated disc
GO:0014894 ISS response to denervation involved in regulation of muscle adaptation
GO:0016020 IEA membrane
GO:0016021 IDA integral component of membrane
GO:0016328 TAS lateral plasma membrane
GO:0017134 IPI fibroblast growth factor binding
GO:0019228 IBA neuronal action potential
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0021537 ISS telencephalon development
GO:0021549 ISS cerebellum development
GO:0030315 IDA T-tubule
GO:0030506 IDA ankyrin binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0035725 IDA sodium ion transmembrane transport
GO:0042383 IDA sarcolemma
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0044325 IPI ion channel binding
GO:0045760 ISS positive regulation of action potential
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050998 IPI nitric-oxide synthase binding
GO:0051899 IDA membrane depolarization
GO:0055085 IEA transmembrane transport
GO:0060048 IMP cardiac muscle contraction
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 IMP regulation of atrial cardiac muscle cell membrane depolarization
GO:0060372 IMP regulation of atrial cardiac muscle cell membrane repolarization
GO:0060373 IMP regulation of ventricular cardiac muscle cell membrane depolarization
GO:0071277 IDA cellular response to calcium ion
GO:0086002 IMP cardiac muscle cell action potential involved in contraction
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086006 IDA voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086010 IDA membrane depolarization during action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086046 ISS membrane depolarization during SA node cell action potential
GO:0086067 IMP AV node cell to bundle of His cell communication
GO:0086069 IMP bundle of His cell to Purkinje myocyte communication
GO:0086070 IMP SA node cell to atrial cardiac muscle cell communication
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:0097110 IPI scaffold protein binding
GO:1902305 IDA regulation of sodium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000120420 Scn5a-002 protein_coding Mus_musculus 0 7805
ENSMUST00000065196 Scn5a-201 protein_coding Mus_musculus 0 7727
ENSMUST00000117911 Scn5a-001 protein_coding Mus_musculus 0 7657
ENSMUST00000084787 Scn10a-201 protein_coding Mus_musculus 0 1565
ENSMUST00000021056 Scn4a-001 protein_coding Mus_musculus 0 1495
ENSMUST00000100067 Scn2a1-201 protein_coding Mus_musculus 0 1079
ENSMUST00000028377 Scn2a1-001 protein_coding Mus_musculus 0 1079
ENSMUST00000169900 Scn9a-203 protein_coding Mus_musculus 0 966
ENSMUST00000100063 Scn9a-201 protein_coding Mus_musculus 0 966
ENSMUST00000164384 Scn9a-202 protein_coding Mus_musculus 0 966
ENSMUST00000112354 Scn9a-002 protein_coding Mus_musculus 0 966
ENSMUST00000100064 Scn9a-001 protein_coding Mus_musculus 0 966
ENSMUST00000066432 Scn3a-201 protein_coding Mus_musculus 0 870
ENSMUST00000100069 Scn3a-001 protein_coding Mus_musculus 0 870
ENSMUST00000112371 Scn1a-201 protein_coding Mus_musculus 0 737
ENSMUST00000094951 Scn1a-005 protein_coding Mus_musculus 0 737
ENSMUST00000077489 Scn1a-004 protein_coding Mus_musculus 0 737
ENSMUST00000112366 Scn1a-001 protein_coding Mus_musculus 0 737
ENSDART00000106534 scn4aa-001 protein_coding Danio_rerio 0 619
ENSMUST00000156865 Scn1a-003 processed_transcript Mus_musculus 0 483
ENSDART00000022761 scn8ab-201 protein_coding Danio_rerio 0 399
ENSDART00000151299 scn8ab-001 protein_coding Danio_rerio 0 399
ENSMUST00000126837 Scn3a-002 protein_coding Mus_musculus 0 274
ENSMUST00000144254 Scn2a1-002 protein_coding Mus_musculus 0 272
ENSDART00000011718 scn1a-201 protein_coding Danio_rerio 0 265
ENSDART00000090979 scn1a-202 protein_coding Danio_rerio 0 265
ENSMUST00000138368 Scn2a1-003 processed_transcript Mus_musculus 0 235
ENSMUST00000138934 Scn5a-003 protein_coding Mus_musculus 0 196

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